Coenzyme Q10 supplementation in infertile men with idiopathic asthenozoospermia:: an open, uncontrolled pilot study

被引：90

作者：

Balercia, G ^{[1
]}

Mosca, F ^{[1
]}

Mantero, F ^{[1
]}

Boscaro, M ^{[1
]}

Mancini, A ^{[1
]}

Ricciardo-Lamonica, G ^{[1
]}

Littarru, G ^{[1
]}

机构：

[1] Univ Ancona, Sch Med, Ancona, Italy

来源：

FERTILITY AND STERILITY | 2004年 / 81卷 / 01期

关键词：

asthenozoospermia; coenzyme Q(10) therapy; male infertility;

D O I：

10.1016/j.fertnstert.2003.05.009

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To clarify a potential therapeutic role of coenzyme Q(10) (CoQ(10)) in infertile men with idiopathic asthenozoospermia. Design: Open, uncontrolled pilot study. Patient(s): Infertile men with idiopathic asthenozoospermia. Intervention(s): CoQ(10) was administered orally; semen samples were collected at baseline and after 6 months of therapy. Main Outcome Measure(s): Semen kinetic parameters, including computer-assisted sperm data and CoQ(10) and phosphatidycholine levels. Result(s): CoQ(10) levels increased significantly in seminal plasma and in sperm cells after treatment. Phosphatidylcholine levels also increased. A significant increase was also found in sperm cell motility as confirmed by computer-assisted analysis. A positive dependence (using the Cramer's index of association) was evident among the relative variations, baseline and after treatment, of seminal plasma or intracellular CoQ(10) content and computer-determined kinetic parameters. Conclusion(s): The exogenous administration of CoQ(10) may play a positive role in the treatment of asthenozoospermia. This is probably the result of its role in mitochondrial bioenergetics and its antioxidant properties.

引用

页码：93 / 98

页数：6

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[1] Oxidative stress, DNA damage and the Y chromosome [J].