Synthesis, structural characterization and cytotoxic activity of organotin derivatives of indomethacin

被引：21

作者：

Camacho-Camacho, Carlos ^{[1
]}

Rojas-Oviedo, Irma ^{[1
]}

Paz-Sandoval, M. Angeles ^{[2
]}

Cardenas, Jorge ^{[3
]}

Toscano, Alfredo ^{[3
]}

Gielen, Marcel ^{[4
]}

Sosa, Lidia Barron ^{[5
]}

Bartez, Francisco Sanchez ^{[5
]}

Gracia-Mora, Isabel ^{[5
]}

机构：

[1] Univ Autonoma Metropolitana Iztapalapa, Dept Sistemas Biol, Mexico City 04960, DF, Mexico

[2] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Quim, Mexico City 07000, DF, Mexico

[3] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

[4] Free Univ Brussels, HNMR Unit, Fac Sci Appl, B-1050 Brussels, Belgium

[5] Univ Circuito Exteriors, Fac Quim Edificio E Cd, Mexico City 04510, DF, Mexico

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2008年 / 22卷 / 03期

关键词：

organotin; carboxylates; indomethacin; cytotoxic;

D O I：

10.1002/aoc.1366

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The synthesis, characterization and cytotoxic properties in vitro of tri-n-butyltin 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate (1), tri-phenyltin 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate (2), tetra-n-butyltin[bis1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetato]distannoxane (3) and di-n-butyltin bis-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate (4) are described. These compounds have been characterized by H-1, C-13 and Sn-119 NMR spectroscopy in solution and Sn-119 NMR in the solid state, infrared spectroscopy, elemental analysis and X-ray diffraction for compound 1. The growth inhibition effects of compounds 1-4 against the lung adenocarcinoma cell line SK-LU-1 as well as the cervical cancer cell line HeLa were determined. Compounds 1 and 2 exhibit cytotoxic activity, whereas compounds 3 and 4 are inactive. Copyright (c) 2008 John Wiley & Sons, Ltd.

引用

页码：171 / 176

页数：6

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