Towards High-Efficiency Synthesis of Xenonucleic Acids

Beyond their central role in storing and transmitting genetic information, nucleic acids are renowned for their high-specificity, high-affinity hybridization. In the past several decades, scientists have become increasingly interested in emulating this unique property of nucleic acids using syntheticmimics. Many creative strategies for the synthesis of xenonucleic acids (XNAs) have been developed, with the field ultimately striving for high-efficiency, scalable routes to achieving sequence-controlled XNA synthesis. Emerging strategies in both biology (e.g., directed evolution) and chemistry (e.g., dynamic covalent reactions) are leading to new breakthroughs in XNA synthesis that will make applications of nucleic acids, such as gene therapy, agricultural disease management, and electronics, more accessible.