The role of microglia in the progression of glaucomatous neurodegeneration- a review

被引：46

作者：

Zeng, Hui-Lan ^{[1
]}

Shi, Jing-Ming ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Dept Ophthalmol, Changsha 410011, Hunan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF OPHTHALMOLOGY | 2018年 / 11卷 / 01期

关键词：

glaucoma; microglia; neuroinflammation; OPTIC-NERVE HEAD; RETINAL GANGLION-CELLS; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; TNF-ALPHA; GLIAL-CELLS; MOUSE MODEL; RECEPTOR ANTAGONISTS; VISUAL PATHWAY; ANIMAL-MODEL;

D O I：

10.18240/ijo.2018.01.22

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Glaucoma is a serious leading cause of irreversible blindness worldwide. Reducing intraocular pressure (IOP) does not always stop glaucomatous neurodegeneration and the optic nerve may continue to be damaged in the normal IOP. Microglial activity has been recognized to play essential roles in pathogenesis of the central nervous system (CNS) as well as retinal ganglion cell (RGC) survival. The relationship between the neurodegeneration and the microglia cells in glaucoma is very complicated and still remains unclear. In the present review, we summarize the recent studies of mechanisms of microglia in glaucoma neurodegeneration, which might provide new ways to treat glaucoma.

引用

页码：143 / 149

页数：7

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