Retinal detachment neuropathology and potential strategies for neuroprotection

被引：24

作者：

Kubay, OV

Charteris, DG

Newland, HS

Raymond, GL

机构：

[1] Royal Adelaide Hosp, Retinal Unit, Dept Ophthalmol, Adelaide, SA 5000, Australia

[2] Moorfields Eye Hosp, Vitreoretinal Serv, London, England

[3] Expt Inst Eye Dis & Tissue Therapy, Vitreoretinal Serv, Odessa, Ukraine

来源：

SURVEY OF OPHTHALMOLOGY | 2005年 / 50卷 / 05期

关键词：

animal model; apoptosis; neuroprotection; neurotrophic factors; photoreceptor rescue; postmortem tissue; retinal detachment; retinal reattachment; vertebrate retina;

D O I：

10.1016/j.survophthal.2005.06.004

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Understanding the neuropathology of retinal detachment from postmortem and animal models allows identification of cellular targets, receptors and mediators for pharmacological manipulation. In this review, concepts of retinal detachment and neuropathology are examined at cellular and structural anatomical levels using postmortem and animal model data. Possible neuroprotective strategies are reviewed in the setting of the new environment created by successful retinal reattachment surgery.

引用

页码：463 / 475

页数：13

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[1] ACIDIC AND BASIC FIBROBLAST GROWTH-FACTOR MESSENGER-RNAS ARE EXPRESSED BY SKELETAL-MUSCLE SATELLITE CELLS [J].