Xanthones from the roots of Polygola caudata and their antioxidation and vasodilatation Activities in vitro

被引:44
作者
Lin, LL
Huang, F
Chen, SB
Yang, DJ
Chen, SL [1 ]
Yang, JS
Xiao, PG
机构
[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
[2] Peking Union Med Coll, Inst Med Plant Dev, Beijing, Peoples R China
[3] Chinese Acad Med Sci, Beijing 100037, Peoples R China
关键词
D O I
10.1055/s-2005-864108
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Three new xanthones, 2-hydroxy-1,6,7-trimethoxyxanthone (1), 1,4-dimethoxy-2,3-methylenedioxyxanthone (2), and 7-hydroxy-1,2-dimethoxyxanthone (3), together with five known compounds, 2,7-dihydroxy-1-methoxyxanthone (4),1-methoxy-2,3methylenedioxyxanthone (5), 7-hydroxy-1-methoxyxanthone (6), euxanthone (1,7-dihydroxyxanthone) (7), and gentitein (1,3,7-trihydroxyxanthone) (8), were isolated from the roots of Polygala caudata. Their structures were established on the basis of spectral evidence. In the antioxidation activity screening in vitro with luminol chemiluminescence methods, compounds 1 - 5 and 7 and 8 showed H2O2 scavenger activity, with a scavenging effect of 58.4 - 94.5% at 10 mu g/mL, and 26.0 - 84.7% at 2 mu g/ mL. Compounds 4 and 8 also exhibited scavenging effects on the reactive oxygen free radicals produced by macrophage respiratory bursts, with a scavenging effect of 71.7% and 63.4% at 10 mu g/mL, 41.2% and 47.8% at 2 mu g/mL, respectively. In the vasodilatation assay, compounds 4 - 7 exhibited relaxing activity on the contractions evoked by KCl in Wistar rat thoracic aorta rings in a dose-dependent manner.
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页码:372 / 375
页数:4
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