Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Cytokines of Atopic Dermatitis in Japanese Adults: A Double-Blind, Randomized, Clinical Trial
被引:56
作者:
Inoue, Yusuke
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, JapanYokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, Japan
Inoue, Yusuke
[1
]
Kambara, Takeshi
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Med Ctr, Dept Dermatol, Yokohama, JapanYokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, Japan
Kambara, Takeshi
[2
]
Murata, Naoko
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, JapanYokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, Japan
Murata, Naoko
[1
]
Komori-Yamaguchi, Junko
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, JapanYokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, Japan
Komori-Yamaguchi, Junko
[1
]
Matsukura, Setsuko
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Med Ctr, Dept Dermatol, Yokohama, JapanYokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, Japan
Matsukura, Setsuko
[2
]
Takahashi, Yukitoshi
论文数: 0引用数: 0
h-index: 0
机构:
Shizuoka Inst Epilepsy & Neurol Disorders, Natl Epilepsy Ctr, Shizuoka, JapanYokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, Japan
Takahashi, Yukitoshi
[3
]
Ikezawa, Zenro
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, JapanYokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, Japan
Ikezawa, Zenro
[1
]
Aihara, Michiko
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, JapanYokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, Japan
Aihara, Michiko
[1
]
机构:
[1] Yokohama City Univ, Dept Environm Immuno Dermatol, Grad Sch Med, Yokohama 2360001, Japan
[2] Yokohama City Univ, Med Ctr, Dept Dermatol, Yokohama, Japan
Objectives: Several studies on lactobacilli have demonstrated they are effective against atopic dermatitis (AD) in children, but there are very few reports of their effects in adults. We investigated the changes in AD symptoms in adults after the ingestion of the Lactobacillus acidophilus strain L-92 (L92), which has been shown to have a curative effect on AD in children. Methods: A double-blind, parallel-group, placebo- controlled comparison was performed on 49 AD patients aged = 16 years using heat-killed L-92. Skin lesions were assessed using the SCORing AD (SCORAD) index before the start of L-92 ingestion and 4 and 8 weeks after ingestion. Serum cytokine and blood marker levels were measured 8 weeks after the start of L-92 ingestion. Results: The group that ingested L-92 had lower SCORAD scores than the controls (p = 0.002). The L-92 group also had decreased ratios of change for eosinophil count (p = 0.03) and increased ratios of change for serum TGF-beta (p = 0.03). Ratios of change for serum TGF-beta rose significantly (p = 0.04) in patients showing mitigated symptoms with L-92 administration. Conclusions: Administration of heat-killed L-92 was effective for AD symptoms in adults. L-92 may contribute to the suppression of Th2-dominant inflammation. Our preliminary trial is the first to report the effects of L-92 on adult AD. (C) 2015 S. Karger AG, Basel
机构:
Calpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, JapanCalpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, Japan
Ashida, Nobuhisa
;
Yanagihara, Sae
论文数: 0引用数: 0
h-index: 0
机构:
Calpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, JapanCalpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, Japan
Yanagihara, Sae
;
Shinoda, Tadashi
论文数: 0引用数: 0
h-index: 0
机构:
Calpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, JapanCalpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, Japan
Shinoda, Tadashi
;
Yamamoto, Naoyuki
论文数: 0引用数: 0
h-index: 0
机构:
Calpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, JapanCalpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, Japan
机构:
Juntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Chiba, Yukihide
;
Shida, Kan
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, Japan
Yakult Cent Inst Microbiol Res, Tokyo, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Shida, Kan
;
Nagata, Satoru
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Nagata, Satoru
;
Wada, Mariko
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Wada, Mariko
;
Bian, Lei
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Bian, Lei
;
Wang, Chongxin
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Wang, Chongxin
;
Shimizu, Toshiaki
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Shimizu, Toshiaki
;
Yamashiro, Yuichiro
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Yamashiro, Yuichiro
;
Kiyoshima-Shibata, Junko
论文数: 0引用数: 0
h-index: 0
机构:
Yakult Cent Inst Microbiol Res, Tokyo, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Kiyoshima-Shibata, Junko
;
Nanno, Msanobu
论文数: 0引用数: 0
h-index: 0
机构:
Yakult Cent Inst Microbiol Res, Tokyo, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Nanno, Msanobu
;
Nomoto, Koji
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, Japan
Yakult Cent Inst Microbiol Res, Tokyo, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
机构:
Calpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, JapanCalpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, Japan
Ashida, Nobuhisa
;
Yanagihara, Sae
论文数: 0引用数: 0
h-index: 0
机构:
Calpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, JapanCalpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, Japan
Yanagihara, Sae
;
Shinoda, Tadashi
论文数: 0引用数: 0
h-index: 0
机构:
Calpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, JapanCalpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, Japan
Shinoda, Tadashi
;
Yamamoto, Naoyuki
论文数: 0引用数: 0
h-index: 0
机构:
Calpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, JapanCalpis Co Ltd, Microbiol & Fermentat Lab, Chuo Ku, Sagamihara, Kanagawa 2520206, Japan
机构:
Juntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Chiba, Yukihide
;
Shida, Kan
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, Japan
Yakult Cent Inst Microbiol Res, Tokyo, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Shida, Kan
;
Nagata, Satoru
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Nagata, Satoru
;
Wada, Mariko
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Wada, Mariko
;
Bian, Lei
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Bian, Lei
;
Wang, Chongxin
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Wang, Chongxin
;
Shimizu, Toshiaki
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Shimizu, Toshiaki
;
Yamashiro, Yuichiro
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Yamashiro, Yuichiro
;
Kiyoshima-Shibata, Junko
论文数: 0引用数: 0
h-index: 0
机构:
Yakult Cent Inst Microbiol Res, Tokyo, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Kiyoshima-Shibata, Junko
;
Nanno, Msanobu
论文数: 0引用数: 0
h-index: 0
机构:
Yakult Cent Inst Microbiol Res, Tokyo, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan
Nanno, Msanobu
;
Nomoto, Koji
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Div Lab Probiot Res, Bunkyo Ku, Tokyo 1138421, Japan
Yakult Cent Inst Microbiol Res, Tokyo, JapanJuntendo Univ, Sch Med, Dept Paediat, Bunkyo Ku, Tokyo 1138421, Japan