Serum S100B levels in patients with epidural haematomas

被引：23
作者：
Undén, J [1 ]
Bellner, J [1 ]
Astrand, R [1 ]
Romner, B [1 ]
机构：
[1] Univ Lund Hosp, Dept Neurosurg, Neurointens care Unit NIVA, S-22185 Lund, Sweden
来源：
BRITISH JOURNAL OF NEUROSURGERY | 2005年 / 19卷 / 01期
关键词：
epidural/intracranial haematoma/haematoma; head/brain injury; S100B/S100/S-100;
D O I：
10.1080/02688690500089381
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Protein S100B is today the most promising biomarker for cerebral injury. A welcomed area for the use of such a marker is in the early stages of head trauma and diagnosis of brain injury, in particular epidural haematomas. We report five consecutive cases of epidural haematoma where serum samples for S100B were drawn at admission. Three of the patients showed low levels of S100B (<= 0.2 mu g/l). One patient with a large epidural haematoma with radiological signs of cerebral herniation displayed normal levels (0.14 mu g/l) of S100B 3.5 h after the initial head trauma. Normal S100B levels in serum do not predict normal intracranial findings. S100B may be unreliable as a marker for epidural haematomas after closed head injury.
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收藏
页码：43 / 45
页数：3
相关论文
共 15 条
  • [1] High serum S100B levels for trauma patients without head injuries
    Anderson, RE
    Hansson, LO
    Nilsson, O
    Dijlai-Merzoug, R
    Settergren, G
    [J]. NEUROSURGERY, 2001, 48 (06) : 1255 - 1258
  • [2] Böttiger BW, 2001, CIRCULATION, V103, P2694
  • [3] Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: Swedish population based cohort study
    Hall, P
    Adami, HO
    Trichopoulos, D
    Pedersen, NL
    Lagiou, P
    Ekbom, A
    Ingvar, M
    Lundell, M
    Granath, F
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2004, 328 (7430): : 19 - 21
  • [4] Release of glial tissue-specific proteins after acute stroke - A comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein
    Herrmann, M
    Vos, P
    Wunderlich, MT
    de Bruijn, CHMM
    Lamers, KJB
    [J]. STROKE, 2000, 31 (11) : 2670 - 2677
  • [5] Biochemical serum markers of traumatic brain injury
    Ingebrigtsen, T
    Romner, B
    [J]. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2002, 52 (04): : 798 - 808
  • [6] JENNETT B, 1996, J NEUROL NEUROSUR PS, V60, P101
  • [7] Elimination of S100B and renal function after cardiac surgery
    Jönsson, H
    Johnsson, P
    Höglund, P
    Alling, C
    Blomquist, S
    [J]. JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2000, 14 (06) : 698 - 701
  • [8] KRAUS JF, 1993, HEAD INJURY
  • [9] Fatal secondary increase in serum S-100B protein after severe head injury - Report of three cases
    Raabe, A
    Seifert, V
    [J]. JOURNAL OF NEUROSURGERY, 1999, 91 (05) : 875 - 877
  • [10] ANALYSIS OF MANAGEMENT IN 33 CLOSED HEAD-INJURY PATIENTS WHO TALKED AND DETERIORATED
    ROCKSWOLD, GL
    LEONARD, PR
    NAGIB, MG
    [J]. NEUROSURGERY, 1987, 21 (01) : 51 - 55
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