A Novel Method for Diagnosing Cirrhosis in Patients with Chronic Hepatitis B: Artificial Neural Network Approach

被引：25

作者：

Raoufy, Mohammad Reza ^{[2
]}

Vahdani, Parviz ^{[3
]}

Alavian, Seyed Moayed ^{[4
]}

Fekri, Sahba ^{[5
]}

Eftekhari, Parivash ^{[2
]}

Gharibzadeh, Shahriar ^{[1
]}

机构：

[1] Amirkabir Univ Technol, Fac Biomed Engn, Neuromuscular Syst Lab, Tehran, Iran

[2] Tarbiat Modares Univ, Sch Med Sci, Dept Physiol, Tehran, Iran

[3] Logman Hosp, Dept Infect Dis, Tehran, Iran

[4] Baqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, Iran

[5] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran

来源：

JOURNAL OF MEDICAL SYSTEMS | 2011年 / 35卷 / 01期

关键词：

Cirrhosis; Chronic hepatitis B; Artificial neural network; Logistic regression; Laboratory data; LIVER-BIOPSY; PREDICTION; FIBROSIS; INFECTION; VIRUS; NEED;

D O I：

10.1007/s10916-009-9348-8

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

We designed an artificial neural network (ANN) to diagnose cirrhosis in patients with chronic HBV infection. Routine laboratory data (PT, INR, platelet count, direct bilirubin, AST/ALT, AST/PLT) and age were collected from 144 patients. Cirrhosis in these patients was diagnosed by liver biopsy. The ANN's ability was assessed using receiver-operating characteristic (ROC) analysis and the results were compared with a logistic regression model. Our results indicate that the neural network analysis is likely to provide a non-invasive, accurate test for diagnosing cirrhosis in chronic HBV-infected patients, only based on routine laboratory data.

引用

页码：121 / 126

页数：6

共 17 条

[11] Prediction of significant fibrosis in hepatitis C virus infected liver transplant recipients by artificial neural network analysis of clinical factors
Piscaglia, Fabio
Cucchetti, Alessandro
Benlloch, Salvador
Vivarelli, Marco
Berenguer, Joaquin
Bolondi, Luigi
Danielle Pinna, Antonio
Berenguer, Marina
[J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2006, 18 (12) : 1255 - 1261
[12] Prediction of liver fibrosis and cirrhosis in chronic hepatitis B infection by serum proteomic fingerprinting: A pilot study
Poon, TCW
Hui, AY
Chan, HLY
Ang, IL
Chow, SM
Wong, N
Sung, JJY
[J]. CLINICAL CHEMISTRY, 2005, 51 (02) : 328 - 335
[13] Non invasive fibrosis biomarkers reduce but not substitute the need for liver biopsy
Sebastiani, Giada
Alberti, Alfredo
[J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (23) : 3682 - 3694
[14] MEASURING THE ACCURACY OF DIAGNOSTIC SYSTEMS
SWETS, JA
[J]. SCIENCE, 1988, 240 (4857) : 1285 - 1293
[15] Advantages and disadvantages of using artificial neural networks versus logistic regression for predicting medical outcomes
Tu, JV
[J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 1996, 49 (11) : 1225 - 1231
[16] Diagnosis of liver cirrhosis - A comparison of modified ultrasound and laparoscopy in 100 consecutive patients
Weickert, U
Buttmann, A
Jakobs, R
Schilling, D
Eickhoff, A
Riemann, JF
[J]. JOURNAL OF CLINICAL GASTROENTEROLOGY, 2005, 39 (06) : 529 - 532
[17] Zhuang H, 2007, CHINESE MED J-PEKING, V120, P2159

← 1 2 →