Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds

被引：20

作者：

de Oliveira, Cledualdo Soares ^{[1
]}

Falcao-Silva, Vivyanne dos Santos ^{[3
]}

Siqueira-Junior, Jose Pinto ^{[3
]}

Harding, David Peter ^{[1
]}

Lira, Bruno Freitas ^{[1
]}

Fernandes Lorenzo, Jorge Goncalo ^{[2
]}

Barbosa-Filho, Jose Maria ^{[2
]}

de Athayde-Filho, Petronio Filgueiras ^{[1
]}

机构：

[1] Univ Fed Paraiba, Dept Chem, BR-58059 Joao Pessoa, PB, Brazil

[2] Univ Fed Paraiba, Pharmaceut Technol Lab, BR-58051 Joao Pessoa, PB, Brazil

[3] Univ Fed Paraiba, Dept Mol Biol, BR-58059 Joao Pessoa, PB, Brazil

来源：

MOLECULES | 2011年 / 16卷 / 03期

关键词：

mesoionic compounds; modulation of drug resistance; efflux pump inhibitor; MULTIDRUG-RESISTANCE; ABSORPTION;

D O I：

10.3390/molecules16032023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two salts of the mesoionic compounds 1,4-diphenyl-5-(5-nitro-2-furanyl)-1,3,4thiadiazolium-2-thiol chloride (MC-1) and 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4thiadiazolium-2-phenylamine chloride (MC-2) were synthesized utilizing 1,4-diphenyl-thiosemicarbazide and 5-nitro-2-furoyl chloride as starting materials. Their structures were characterized by IR, H-1-NMR, C-13-NMR and elemental analysis. These compounds were analyzed for their influence on the effectiveness of norfloxacin, tetracycline, and erythromycin (standard antibiotics) against resistant strains of Staphylococcus aureus. MC-1 and MC-2, at sub-inhibitory concentrations of 16 mu g/mL, favourably modulated the antibiotic activity of tetracycline by 16-and 32-fold, respectively (MIC), and that of erythromycin by 4-fold.

引用

页码：2023 / 2031

页数：9

共 36 条

[1]

[Anonymous], 2005, M100S15 CLSI NCCLS

[2]

[Anonymous], 1995, HETEROCYCL COMMUN, DOI [DOI 10.1515/HC.1995.1.2-3.129, 10.1515/HC.1995.1.2-3.129]

[3] Triterpenes and phenolic compounds isolated from the aerial parts of Herissantia tiubae and evaluation of 5,4′,-dihydroxy-3,6,7,8,3′-pentamethoxyflavone as a modulator of bacterial drug resistance [J].

Antas e Silva, Davi ;

Falcao-Silva, Vivyanne S. ;

Serrano Gomes, Ana Yara ;

da Costa, Danielly Albuquerque ;

Lemos, Virginia Soares ;

Agra, Maria de Fatima ;

Braz-Filho, Raimundo ;

Siqueira-Junior, Jose P. ;

Vanderlei de Souza, Maria de Fatima .

PHARMACEUTICAL BIOLOGY, 2009, 47 (04) :279-284

[4]

Athayde-Filho P. F., 1999, ACTA FARM BONAER, V18, P17

[5] Probing the nuclear susceptibility of mesoionic compounds using two-beam coupling with chirp-controlled pulses [J].

Bosco, Carlos A. C. ;

Maciel, Glauco S. ;

Rakov, Nikifor ;

de Araujo, Cid B. ;

Acioli, Lucio H. ;

Simas, Alfredo M. ;

Athayde-Filho, Petronio F. ;

Miller, Joseph .

CHEMICAL PHYSICS LETTERS, 2007, 449 (1-3) :101-106

[6] Exploiting current understanding of antibiotic action for discovery of new drugs [J].

Chopra, I ;

Hesse, L ;

O'Neill, AJ .

JOURNAL OF APPLIED MICROBIOLOGY, 2002, 92 :4S-15S

[7]

de Athayde PF, 2000, SYNTHESIS-STUTTGART, P1565

[8] A kinetic study of the thermal decomposition of mesoionic compounds within scope of its application in nonlinear optical devices [J].

de Morais, Soraya Alves ;

da Silva Morais, Crislene Rodrigues ;

de Athayde Filho, Petronio Filgueiras ;

Lira, B. Freitas ;

Taveira Rocha do Nascimento, Railda Shelsea .

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2009, 97 (02) :437-441

[9]

deAthayde PF, 1996, HETEROCYCL COMMUN, V2, P573

[10] Modulation of Drug Resistance in Staphylococcus aureus by a Kaempferol Glycoside from Herissantia tiubae (Malvaceae) [J].

Falcao-Silva, Vivyanne S. ;

Silva, Davi A. ;

Souza, Maria de Fatima V. ;

Siqueira-Junior, Jose P. .

PHYTOTHERAPY RESEARCH, 2009, 23 (10) :1367-1370

← 1 2 3 4 →