Enantioselective Synthesis of Core Structures of Hydramicromelins A, B and C

被引：2

作者：

Sun, Moran ^{[1
,2
]}

Dai, Lei ^{[1
,2
]}

Yang, Hua ^{[1
,2
]}

Liu, Hongmin ^{[1
,2
]}

Yu, Dequan ^{[1
]}

机构：

[1] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China

[2] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450001, Henan, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 09期

基金：

中国国家自然科学基金;

关键词：

hydramicromelins A; B and C; 2,3]-Meisenheimer rearrangement; chiral tertiary alcohol; epoxidation; ALPHA-KETOESTERS; REARRANGEMENT; DIMETHYLZINC; CONSTRUCTION;

D O I：

10.6023/cjoc201802017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydramicromelins A similar to C are coumarin compounds with unique chemical structure and biological activity. With [2,3]-Meisenheimer rearrangemen as a key reaction which has been developed in our laboratory, the core structures of Hydramicromelin A, B and C were synthesized from L-phenylglycine. The route included Wittig reaction, [2,3]-Meisenheimer rearrangement, epoxidation and dihydroxylation reaction, and it was high-yield and high-enantioselectivity.

引用

页码：2443 / 2449

页数：7

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