Phosphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor clinical outcome

被引：70
作者：
Cheong, JW
Eom, JI
Maeng, HY
Lee, ST
Hahn, JS
Ko, YW
Min, YH
机构：
[1] Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South Korea
[2] Yonsei Univ, Coll Med, Clin Res Ctr, Seoul 120752, South Korea
[3] Yonsei Univ, Coll Med, Brain Korean 21 Project Med Sci, Seoul 120752, South Korea
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2003年 / 122卷 / 03期
关键词：
PTEN; constitutive phosphorylation; AML; Akt; prognosis;
D O I：
10.1046/j.1365-2141.2003.04452.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Phosphorylation of PTEN (phosphatase and tensin homologue) affects PTEN protein stability and function. In this study, phosphorylated PTEN (pPTEN) was observed in 45 (73.8%) of 61 cases with acute myeloid leukaemia (AML). Phosphorylation of Akt and its downstream molecules [FKHR; Forkhead (Drosophila ) homologue 1; and GSK-3beta; glycogen synthase kinase 3 beta] was significantly associated with pPTEN (P < 0.001). The complete remission rates were not different with respect to pPTEN, but overall survival was significantly shorter in patients with pPTEN (P < 0.05). Constitutive PTEN phosphorylation may add insight into the molecular pathogenesis of AML, and may be a new parameter for an unfavourable outcome.
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页码：454 / 456
页数：3
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