Tongue Stiffness is Lower in Patients with Obstructive Sleep Apnea during Wakefulness Compared with Matched Control Subjects

被引:47
作者
Brown, Elizabeth C. [1 ,2 ]
Cheng, Shaokoon [1 ,4 ,5 ]
McKenzie, David K. [2 ,3 ]
Butler, Jane E. [1 ,5 ]
Gandevia, Simon C. [1 ,2 ]
Bilston, Lynne E. [1 ,2 ]
机构
[1] Neurosci Res Australia, Randwick, NSW 2031, Australia
[2] Univ New S Wales, Prince Wales Clin Sch, Sydney, NSW 2052, Australia
[3] Prince Wales Hosp, Sydney, NSW, Australia
[4] Macquarie Univ, Dept Engn, N Ryde, NSW 2109, Australia
[5] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
collapsibility; elastography; obstructive sleep apnea; UPPER AIRWAY; HUMAN GENIOGLOSSUS; PALATOPHARYNGEAL MUSCLE; EXTRACELLULAR-MATRIX; MR ELASTOGRAPHY; OBESE-PATIENTS; ACTIVATION; MECHANISMS;
D O I
10.5665/sleep.4566
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study Objectives: This study aimed to determine whether tongue stiffness (shear modulus) in patients with obstructive sleep apnea (OSA) is different for controls matched for age, sex, and body mass index (BMI), and to investigate the effect of continuous positive airway pressure (CPAP) on stiffness. Design: Controlled experimental study. Setting: Medical research institute. Participants: Patients with OSA and age-, sex-, and BMI-matched healthy controls. Measurements: Magnetic resonance elastography was performed in nine patients with OSA (apnea-hypopnea index (AHI) > 15 events/h) and seven controls (AHI < 10 events/h) matched for age, sex, and BMI. Six of these OSA subjects were also scanned while 10 cmH(2)O CPAP was applied. Mean isotropic shear modulus and anisotropic shear moduli parallel and perpendicular to the muscle fascicles in the tongue were calculated. Results: Tongue shear modulus in patients with OSA was lower than that in matched controls (2.68 +/- 0.35 (mean +/- standard deviation) kPa versus 2.98 +/- 0.44 kPa, P < 0.001). Shear modulus decreased with increasing AHI (R = -0.496, P = 0.043), but not age, BMI, or percentage tongue fat. Anisotropic analysis revealed that reduction in stiffness was greatest parallel to the muscle fibers. CPAP had no significant effect on tongue shear modulus. Conclusions: In awake subjects with obstructive sleep apnea, the tongue is less stiff than in similar healthy subjects and this difference occurs in the muscle fiber direction. CPAP did not significantly reduce tongue stiffness. Thus, any change in neural drive to genioglossus during wakefulness is insufficient to restore normal tongue stiffness.
引用
收藏
页码:537 / 544
页数:8
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