Multifunctional drug delivery system using starch-alginate beads for controlled release

被引:31
作者
Kim, YJ
Park, HG
Yang, YL
Yoon, Y
Kim, S
Oh, E
机构
[1] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Taejon 305701, South Korea
[2] Korea Res Inst Biosci & Biotechnol, Natl Genome Informat Ctr, Taejon 305333, South Korea
[3] Korea Inst Oriental Med, Dept Med Res, Taejon 305811, South Korea
[4] Cosbiotech Inc, Taejon 305811, South Korea
关键词
alginate bead; drug; delivery system; controlled release; coating; starch;
D O I
10.1248/bpb.28.394
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Utilizing starch-containing alginate beads, a novel drug delivery system (DDS) was developed. With the starch inside, the composite bead could be dried in its original bead shape and handled in the dried state. By employing alginate multi-coating strategy on the starch-alginate beads, detained or controlled release was efficiently achieved and successfully demonstrated for a model peptide drug, L-phenylaianine. The initial latent time and release rate of the drug inside the beads were able to be controlled simply by varying the number of multicoatings. While the latent time for the initial release was negligible for non-coated starch-alginate beads, the latent times of beads coated one, two, and four times increased to 15, 30, and 70 min, respectively. Furthermore, the alginate component of the composite beads could adsorb and remove heavy metals such as lead from the body. These multifunctional beads combined with the novel coating process will greatly benefit alginate gel-based DDS.
引用
收藏
页码:394 / 397
页数:4
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