The Role of Notch Signaling in Endothelial Progenitor Cell Biology

被引：31
|
作者：
Kwon, Sang-Mo [1 ,2 ]
Alev, Cantas [3 ,4 ]
Asahara, Takayuki [1 ,3 ,4 ]
机构：
[1] Tokai Univ, Sch Med, Dept Regenerat Med Sci, Isehara, Kanagawa 2591193, Japan
[2] CHA Univ, Lab Vasc Med & Stem Cell Biol, Seoul, South Korea
[3] Inst Biomed Res & Innovat, Vasc Regenerat Res Grp, Kobe, Hyogo, Japan
[4] RIKEN Ctr Dev Biol, Lab Stem Cell Biol, Kobe, Hyogo, Japan
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2009年 / 19卷 / 05期
关键词：
INHIBITS TUMOR-GROWTH; VASCULAR DEVELOPMENT; EMBRYONIC LETHALITY; ANGIOGENESIS; NEOVASCULARIZATION; ACTIVATION; ARTERIAL; IDENTITY; JAGGED1; NICHE;
D O I：
10.1016/j.tcm.2009.10.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
It is generally accepted that endothelial progenitor cells (EPCs) can promote postnatal neovascularization and be used for vascular regeneration, thus representing a promising new tool for the treatment of cardiovascular diseases. However, the exact molecular mechanisms and signaling pathways regulating the proliferation, differentiation, and migration of EPCs; their interaction with niche cells; and their regenerative capacity still remain elusive. The Notch signaling pathway shown to be important for the maintenance and differentiation of various stem and progenitor populations is also involved in EPC regulation. In this review, we will summarize the current knowledge about the pivotal role of Notch signaling in EPC biology and EPC-mediated vascular regeneration. (Trends Cardiovasc Med 2009;19:170-173) (C) 2009, Elsevier Inc.
引用
收藏
页码：170 / 173
页数：4
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