SYNTHESIS FROM l-MENTHOL OF OPTICALLY ACTIVE MACROHETEROCYCLES CONTAINING ESTER, AZINE, OR HYDRAZIDE GROUPS

被引：1

作者：

Ishmuratov, G. Yu. ^{[1
]}

Mingaleeva, G. R. ^{[1
]}

Shakhanova, O. O. ^{[1
]}

Muslukhov, R. R. ^{[1
]}

Vyrypaev, E. M. ^{[1
]}

Tolstikov, A. G. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Organ Chem, Ufa Sci Ctr, Ufa 450054, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2011年 / 47卷 / 02期

关键词：

l-menthol; bis[(3; R)-3; 7; '-dimethyl-6; '-oxooctyl; pentanedioate; '-oxooctyl]hexanedioate; optically pure macrocyclic azinodiesters and diesterdihydrazides; synthesis;

D O I：

10.1007/s10600-011-9883-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A synthesis of optically pure methyl-and isopropyl-branched 21-, 22-, 28-, and 29-membered azinodiesters and diesterdihydrazides from l-menthol using [2+1]-condensation of (6R)-8-hydroxy-2,6-dimethyloctan-3-one and glutaric and adipic acid chlorides and [1+1]-reaction of the intermediate diketodiesters with hydrazine hydrate and glutaric acid dihydrazide was developed.

引用

页码：206 / 209

页数：4