Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue-Dendrimer Conjugate in C26 Tumor Bearing Mice

被引：27

作者：

Floyd, William C., III ^{[3
]}

Datta, Gopal K. ^{[2
,3
]}

Imamura, Shinichi ^{[2
]}

Kieler-Ferguson, Heidi M. ^{[3
]}

Jerger, Katherine ^{[1
]}

Patterson, Andrew W. ^{[2
]}

Fox, Megan E. ^{[3
]}

Szoka, Francis C. ^{[1
]}

Frechet, Jean M. J. ^{[3
]}

Ellman, Jonathan A. ^{[4
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn Therapeut Sci & Pharmaceut Chem, San Francisco, CA 94143 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Coll Chem, Berkeley, CA 94720 USA

[4] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

CHEMMEDCHEM | 2011年 / 6卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

antitumor agents; colon carcinoma; dendrimers; drug delivery; tubulysins; DRUG-DELIVERY APPLICATIONS; BIOLOGICAL EVALUATION; NATURAL-PRODUCT; GENE DELIVERY; IN-VITRO; MACROMOLECULAR THERAPEUTICS; ANGIOCOCCUS-DISCIFORMIS; POTENTIAL ANTICANCER; CANCER-CHEMOTHERAPY; DESIGN;

D O I：

10.1002/cmdc.201000377

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Conjugate to ameliorate! Polymeric drug delivery using a synthetic tubulysin analogue in C26 tumor bearing mice is described. A single dose of this conjugate (shown) resulted in a 90 % increase in the average lifespan of the mice as compared to groups given a phosphate-buffered saline control or the free tubulysin analogue. Moreover, 37 % of the mice given the polymeric formulation were tumor free at the conclusion of the study. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：49 / 53

页数：5

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