Tribulusamide A and B, new hepatoprotective lignanamides from the fruits of Tribulus terrestris: Indications of cytoprotective activity in murine hepatocyte culture

被引：66
作者：
Li, JX
Shi, Q
Xiong, QB
Prasain, JK
Tezuka, Y
Hareyama, T
Wang, ZT
Tanaka, K
Namba, T
Kadota, S
机构：
[1] Toyama Med & Pharmaceut Univ, Wakan Yaku Res Inst, Toyama 9300194, Japan
[2] China Pharmaceut Univ, Nanjing, Peoples R China
[3] Natl Res Inst Police Sci, Tokyo, Japan
来源：
PLANTA MEDICA | 1998年 / 64卷 / 07期
关键词：
Tribulus terrestris; Zygophyllaceae; lignanamide; tribulusamide; D-galactosamine; tumor necrosis factor alpha (TNF-alpha); hepatoprotective activity;
D O I：
10.1055/s-2006-957535
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Tribulusamides A (1) and B (2), new lignanamides embracing two cinnamic amide parts joined in a cis configuration, were isolated from the fruits of Tribulus terrestris, together with four known compounds, N-trans-feruloyltyramine (3), terrestriamide (4), M-trans-coumaroyltyramine (5), and beta-sitosterol. The structures were elucidated by 2D-NMR spectroscopy. Addition of compounds 1-5, especially 1 and 2, to primary cultured mouse hepatocytes significantly prevented cell death induced by D-galactosamine (D-GalN)/tumor necrosis factor a: (TNF-alpha).
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页码：628 / 631
页数：4
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