The past decade has seen a surge of research interest in multiple sclerosis and an accelerated expansion of investigative efforts into multiple sclerosis therapeutics. Investigators have continued dissecting the complex immunological perturbations that may contribute to the disease and made major advances in understanding the genetics of multiple sclerosis. This article addresses current investigative issues and offers predictions about where the understanding and treatment of multiple sclerosis may stand at the end of the 21st century's second decade. Mt Sinai J Med 78:268-279, 2011. (C) 2011 Mount Sinai School of Medicine
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Brigham & Womens Hosp, Partners MS Ctr, Brookline, MA 02445 USA
Massachusetts Gen Hosp, Biostat Ctr, Boston, MA 02114 USABrigham & Womens Hosp, Partners MS Ctr, Brookline, MA 02445 USA
Healy, Brian
Chitnis, Tanuja
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Brigham & Womens Hosp, Partners MS Ctr, Brookline, MA 02445 USABrigham & Womens Hosp, Partners MS Ctr, Brookline, MA 02445 USA
Chitnis, Tanuja
Engler, David
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230 TMCB Brigham Young Univ, Dept Stat, Provo, UT 84602 USABrigham & Womens Hosp, Partners MS Ctr, Brookline, MA 02445 USA
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Hosp Univ Vail Hebron, Ctr Esclerosi Multiple Catalunya CEM Cat, Unitat Neuroimmunol, Barcelona 08035, SpainHosp Univ Vail Hebron, Ctr Esclerosi Multiple Catalunya CEM Cat, Unitat Neuroimmunol, Barcelona 08035, Spain
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IRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
IRCCS Osped San Raffaele, Dept Neurol, Via Olgettina 48, I-20132 Milan, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Moiola, Lucia
Barcella, Valeria
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ASST Papa Giovanni XXIII, Dept Neurol, Bergamo, Italy
ASST Papa Giovanni XXIII, Multiple Sclerosis Ctr, Bergamo, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Barcella, Valeria
Benatti, Simone
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ASST Papa Giovanni XXIII, Dept Infect Dis, Bergamo, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Benatti, Simone
Capobianco, Marco
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AOU San Luigi, SCDO Neurol & Reg Reference Multiple Sclerosis Ct, Orbassano, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
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Ist Sci San Raffaele, Div Infect Dis, Milan, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Cinque, Paola
Comi, Giancarlo
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Hosp San Raffaele, Inst Expt Neurol, Milan, Italy
Hosp San Raffaele, Multiple Sclerosis Ctr IRCCS, Milan, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Comi, Giancarlo
Fasolo, Maria Michela
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ASST Fatebenefratelli Sacco Univ Hosp, Div Infect Dis, Dept Infect Dis, Milan, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Fasolo, Maria Michela
Franzetti, Fabio
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Busto Arsizio Hosp, Infect Dis Unit, Busto Arsizio, Italy
Luigi Sacco Univ Hosp, Div Infect Dis 3, Milan, Italy
Luigi Sacco Univ Hosp, Infect Dis Unit, Milan, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Franzetti, Fabio
Galli, Massimo
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Univ Milan, Div Infect Dis 3, ASST Fatebenefratelli Sacco, Dept Biomed & Clin Sci LSacco, Milan, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Galli, Massimo
Gerevini, Simonetta
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IRCCS San Raffaele Sci Inst, Div Neuroradiol, Milan, Italy
Papa Giovanni XXIII Hosp, Dept Neuroradiol, Bergamo, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Gerevini, Simonetta
Meroni, Luca
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Univ Milan, ASST Fatebenefratelli Sacco, Div Infect Dis 3, Milan, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Meroni, Luca
Origoni, Massimo
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Univ Vita Salute San Raffaele, IRCCS Osped San Raffaele, Dept Gynecol & Obstet, Milan, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Origoni, Massimo
Prosperini, Luca
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San Camillo Forlanini Hosp, Dept Neurosci, Rome, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Prosperini, Luca
Puoti, Massimo
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ASST Niguarda Ca Grande Hosp, SC Infect Dis, Milan, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Puoti, Massimo
Scarpazza, Cristina
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机构:
Spedali Civili Brescia, Multiple Sclerosis Ctr, Montichiari, Italy
Univ Padua, Dept Gen Psychol, Padua, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Scarpazza, Cristina
Tortorella, Carla
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San Camillo Forlanini Hosp, Dept Neurosci, Rome, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Tortorella, Carla
Zaffaroni, Mauro
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ASST Valle Olona, Hosp Gallarate, Multiple Sclerosis Ctr, Gallarate, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy
Zaffaroni, Mauro
Riva, Agostino
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Univ Milan, ASST Fatebenefratelli Sacco, Div Infect Dis 3, Milan, ItalyIRCCS Osped San Raffaele, Multiple Sclerosis Ctr, Via Olgettina 48, I-20132 Milan, Italy