Long noncoding RNAs as therapeutic targets to overcome chemoresistance in ovarian cancer

被引：8
作者：
Chen, Linjiao [1 ]
Wang, Jie [1 ]
Liu, Qian [1 ]
机构：
[1] First Hosp Jilin Univ, Dept Reprod Med, Dept Prenatal Genet, Changchun, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷
关键词：
lncRNA; epigenetic; chemoresistance; ovarian cancer; cisplatin; paclitaxel; target; CISPLATIN RESISTANCE; PACLITAXEL RESISTANCE; DRUG-RESISTANCE; SUPPRESSES; KNOCKDOWN; PROMOTES; HOTAIR; CELLS; OVEREXPRESSION; PROLIFERATION;
D O I：
10.3389/fcell.2022.999174
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Long noncoding RNAs (lncRNAs) have been characterized to play an essential role in ovarian tumorigenesis via controlling a variety of cellular processes, such as cell proliferation, invasion, apoptotic death, metastasis, cell cycle, migration, metabolism, immune evasion, and chemoresistance. The one obstacle for the therapeutic efficacy is due to the development of drug resistance in ovarian cancer patients. Therefore, in this review article, we describe the role of lncRNAs in chemoresistance in ovarian cancer. Moreover, we discuss the molecular mechanism of lncRNAs-involved drug resistance in ovarian cancer. We conclude that lncRNAs could be useful targets to overcome chemoresistance and improve therapeutic outcome in ovarian cancer patients.
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页数：10
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[11]   Tissue-based long non-coding RNAs "PVT1, TUG1 and MEG3" signature predicts Cisplatin resistance in ovarian Cancer [J].
El-Khazragy, Nashwa ;
Mohammed, Hayam Fathy ;
Yassin, Mohamed ;
Elghoneimy, K. K. ;
Bayoumy, Walid ;
Hewety, Amr ;
El Magdoub, Hekmat M. ;
Elayat, Wael ;
Zaki, Walid ;
Safwat, Gehan ;
Mosa, Mai ;
Zedan, Khouloud ;
Salem, Salema ;
Bannunah, Azzah M. ;
Mansy, Azza .
GENOMICS, 2020, 112 (06) :4640-4646
[12]   Integrated clinical characteristics and omics analysis identifies a ferroptosis and iron-metabolism-related lncRNA signature for predicting prognosis and therapeutic responses in ovarian cancer [J].
Feng, Songwei ;
Yin, Han ;
Zhang, Ke ;
Shan, Mei ;
Ji, Xuan ;
Luo, Shanhui ;
Shen, Yang .
JOURNAL OF OVARIAN RESEARCH, 2022, 15 (01)
[13]   The Changing Landscape of Gynecologic Cancer Mortality in the United States [J].
Giaquinto, Angela N. ;
Broaddus, Russell R. ;
Jemal, Ahmedin ;
Siegel, Rebecca L. .
OBSTETRICS AND GYNECOLOGY, 2022, 139 (03) :440-442
[14]   Long Noncoding RNA LINC01125 Enhances Cisplatin Sensitivity of Ovarian Cancer via miR-1972 [J].
Guo, Jia ;
Pan, Hua .
MEDICAL SCIENCE MONITOR, 2019, 25 :9844-9854
[15]   HOTAIR promotes paclitaxel resistance by regulating CHEK1 in ovarian cancer [J].
Jiang, Jiahong ;
Wang, Shaohai ;
Wang, Zehua ;
Cai, Jing ;
Han, Lingling ;
Xie, Lisha ;
Han, Qing ;
Wang, Wenwen ;
Zhang, Yifan ;
He, Xiaoqi ;
Yang, Chun .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2020, 86 (02) :295-305
[16]   The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy [J].
Jiang, Wenxiao ;
Pan, Shuya ;
Chen, Xin ;
Wang, Zhi-wei ;
Zhu, Xueqiong .
MOLECULAR CANCER, 2021, 20 (01)
[17]   Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs [J].
Jiang, Wenxiao ;
Xia, Jun ;
Xie, Shangdan ;
Zou, Ruanmin ;
Pan, Shuya ;
Wang, Zhi-wei ;
Assaraf, Yehuda G. ;
Zhu, Xueqiong .
DRUG RESISTANCE UPDATES, 2020, 50
[18]   The Emerging Role of Non-coding RNAs in Drug Resistance of Ovarian Cancer [J].
Lan, Hua ;
Yuan, Jing ;
Zeng, Da ;
Liu, Chu ;
Guo, Xiaohui ;
Yong, Jiahui ;
Zeng, Xiangyang ;
Xiao, Songshu .
FRONTIERS IN GENETICS, 2021, 12
[19]   Roles of a TMPO-AS1/microRNA-200c/TMEFF2 ceRNA network in the malignant behaviors and 5-FU resistance of ovarian cancer cells [J].
Li, Haoshan ;
Zhou, Yan ;
Cheng, Hailing ;
Tian, Jun ;
Yang, Shaoqin .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2020, 115
[20]   Downregulation of circNRIP I Suppresses the Paclitaxel Resistance of Ovarian Cancer via Regulating the miR-2 I I-5p/HOXC8 Axis [J].
Li, Meng ;
Cai, Junna ;
Han, Xiaorui ;
Ren, Yue .
CANCER MANAGEMENT AND RESEARCH, 2020, 12 :9159-9171
12345678