Ethiodized poppyseed oil-based contrast medium is superior to water-based contrast medium during hysterosalpingography regarding image quality improvement and fertility enhancement: A multicentric, randomized and controlled trial

被引：17

作者：

Zhang, Jing ^{[1
]}

Lan, Weishun ^{[2
]}

Wang, Yitang ^{[3
]}

Chen, Kunshan ^{[4
]}

Zhang, Guofu ^{[5
]}

Yang, Wenzhong ^{[2
]}

Chen, Huichun ^{[6
]}

Xu, Wenjian ^{[7
]}

Ma, Jianxin ^{[8
]}

Qin, Wenhua ^{[9
]}

Zhang, Yao ^{[10
]}

Wang, Wuquan ^{[11
]}

Wang, Huichun ^{[12
]}

Dong, Zijun ^{[13
]}

Wang, Yanli ^{[14
]}

Chen, Yi ^{[15
]}

Gang, Ning ^{[16
]}

Tang, Yichuan ^{[17
]}

机构：

[1] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Intervent Radiol, 106 Zhongshan Second Rd, Guangzhou 510080, Guangdong, Peoples R China

[2] Maternal & Child Hlth Hosp Hubei Prov, Dept Med Imaging, Wuhan 430070, Peoples R China

[3] Dalian Municipal Women & Childrens Med Ctr Grp, Dept Intervent Therapy Angiomatol, Dalian 116037, Peoples R China

[4] Guangzhou Women & Childrens Med Ctr, Dept Intervent Radiol, Guangzhou 510080, Peoples R China

[5] Fudan Univ, Dept Radiol, Obstet & Gynecol Hosp, Shanghai 200011, Peoples R China

[6] Chengde Cent Hosp, Reprod Med Ctr, Chengde 067000, Peoples R China

[7] Nanjing Matern & Child Hlth Care Hosp, Dept Intervent Radiol, Nanjing 210004, Peoples R China

[8] Cangzhou Hosp Integrated TCM WM, Reprod Med Ctr, Cangzhou 061899, Peoples R China

[9] Liuzhou Matern & Child Healthcare Hosp, Dept Radiol, Liuzhou 545001, Peoples R China

[10] Mianyang Cent Hosp, Reprod Med Ctr, Mianyang 621000, Peoples R China

[11] Lanzhou Univ, Intervent Radiog, Hosp 2, Lanzhou 730030, Peoples R China

[12] Maternal & Child Hlth Hosp Haidian Dist Beijing, Reprod Ctr, Beijing 100080, Peoples R China

[13] Lianyungang Maternal & Child Hlth Hosp, Dept Radiol, Lianyungang 222000, Peoples R China

[14] Zhengzhou Univ, Dept Intervent, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China

[15] Chenzhou First Peoples Hosp, Med Reprod Ctr, Chenzhou 423000, Peoples R China

[16] Sichuan Univ, West China Second Univ Hosp, Dept Radiol, West China Womens & Childrens Hosp, Chengdu 610066, Peoples R China

[17] Jinjiang Matern & Child Hlth Hosp, Dept Intervent, Chengdu 610016, Peoples R China

来源：

ECLINICALMEDICINE | 2022年 / 46卷

关键词：

Hysterosalpingography; Ethiodized poppyseed oil-based contrast medium; Image quality; Fertility enhancement; Safety; FEMALE INFERTILITY;

D O I：

10.1016/j.eclinm.2022.101363

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The efficacy of ethiodized poppyseed oil in hysterosalpingography (HSG) image quality and fertility enhancement has been revealed, but whether this HSG modality has similar effects in the Chinese population is still unclear. Methods Between July 18, 2017, and December 29, 2019, this multicentric, randomized, two-arm, clinical trial was performed involving 15 medical centers. Infertile women meeting HSG indications were randomly assigned to an oil group and a water group. The coprimary outcome included HSG image quality during HSG and fertility-enhancing effects of HSG. This study was registered on ClinicalTrials.gov (NCT03370575). Findings A total of 1026 subjects were randomly assigned to an oil group (N = 508) and a water group (N = 518). HSG image quality revealed that the oil group had outstanding visualization (all P < 0.001); total image quality scores for uterus opacification or uterine outline (2.9 +/- 0.4 vs. 2.7 +/- 0.5), fallopian tube outline (2.3 +/- 0.8 vs. 1.7 +/- 0.7), fimbrial rugae (1.7 +/- 1.0 vs. 1.3 +/- 0.8), fallopian tube spillage (2.1 +/- 0.9 vs. 1.6 +/- 0.8), peritoneal distribution (2.6 +/- 0.9 vs. 2.1 +/- 1.0) and diagnostic quality (11.6 +/- 3.4 vs. 9.5 +/- 3.1) (all P < 0.001) were higher in the oil group than in the water group. Regarding fertility-enhancing evaluation, the oil group showed an increased cumulative on-going pregnancy rate, on-going pregnancy within 6 months (29.1% vs. 20.1%), clinical pregnancy (39.5% vs. 29.1%) and live birth >= 24 weeks of gestation (36.1% vs. 27.7%) but a shorter time to pregnancy than the water group (all P < 0.01). Concerning adverse events, the oil group showed a lower occurrence rate of abdominal pain and vaginal bleeding after HSG (both P < 0.01). Interpretation Ethiodized poppyseed oil-based contrast is superior to water-based contrast during HSG in terms of image quality improvement and fertility enhancement. This study indicates the priority of the application of ethiodized poppyseed oil-based contrast during the HSG procedure in infertile patients. Copyright (C) 2022 The Authors. Published by Elsevier Ltd.

引用

页数：12

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