Comparison of 'time to detection' values between BacT/ALERT VIRTUO and BacT/ALERT 3D instruments for clinical blood culture samples

被引:17
作者
Congestri, Francesco [1 ]
Pedna, Maria Federica [1 ]
Fantini, Michela [1 ]
Samuelli, Michela [1 ]
Schiavone, Pasqua [1 ]
Torri, Arianna [1 ]
Bertini, Stefania [1 ]
Sambri, Vittorio [1 ,2 ]
机构
[1] Greater Romagna Hub Lab, Unit Microbiol, Piazza Liberaz 60, I-47522 Pievesestina Di Cesena, FC, Italy
[2] Univ Bologna, DIMES, Bologna, Italy
关键词
Bacteraemia; Sepsis; Blood culture systems; Microorganisms causing sepsis; Time to detection; Early sepsis detection; VIRTUO system; BacT/ALERT 3D system; SEPTIC SHOCK; BACTEREMIA; DIAGNOSIS; SEPSIS;
D O I
10.1016/j.ijid.2017.06.012
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: The early detection of bacteraemia and fungemia is of paramount importance to guide antimicrobial therapy in septic patients. In this study the 'time to detection' (TTD) value for the new blood culture system BacT/ALERT VIRTUO (VIRTUO) was evaluated in 1462 positive clinical bottles and compared with the TTD for 1601 positive clinical bottles incubated in the BacT/ALERT 3D system (BTA-3D). Methods: The most representative microorganisms isolated from bottles incubated in both blood culture systems were divided into eight categories (in order of frequency): coagulase-negative staphylococci (CoNS), Escherichia coli, Enterobacteriaceae (other than E. coli), Staphylococcus aureus, Enterococcus spp, viridans group streptococci, Pseudomonas aeruginosa, and Candida spp. Results: The comparison of TTD values for the two blood culture systems strongly indicated that growth of the first five groups listed above was detected earlier with VIRTUO than with BTA-3D (p < 0.05). Conclusions: The new VIRTUO blood culture system can reduce the TTD for more than 75% of isolated microorganisms. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
引用
收藏
页码:1 / 5
页数:5
相关论文
共 13 条
[1]   Controlled Evaluation of the New BacT/Alert Virtuo Blood Culture System for Detection and Time to Detection of Bacteria and Yeasts [J].
Altun, Osman ;
Almuhayawi, Mohammed ;
Luthje, Petra ;
Taha, Rubina ;
Ullberg, Mans ;
Ozenci, Volkan .
JOURNAL OF CLINICAL MICROBIOLOGY, 2016, 54 (04) :1148-1151
[2]  
Cheong YS, 2016, 26 ECCMID AMST NETH
[3]  
Deol P, 2016, 26 ECCMID AMST NETH
[4]   Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department [J].
Gaieski, David F. ;
Mikkelsen, Mark E. ;
Band, Roger A. ;
Pines, Jesse M. ;
Massone, Richard ;
Furia, Frances F. ;
Shofer, Frances S. ;
Goyal, Munish .
CRITICAL CARE MEDICINE, 2010, 38 (04) :1045-1053
[5]   Updated review of blood culture contamination [J].
Hall, Keri K. ;
Lyman, Jason A. .
CLINICAL MICROBIOLOGY REVIEWS, 2006, 19 (04) :788-+
[6]   Controlled clinical laboratory comparison of BACTEC plus aerobic/F resin medium with BacT/Alert aerobic FAN medium for detection of bacteremia and fungemia [J].
Jorgensen, JH ;
Mirrett, S ;
McDonald, LC ;
Murray, PR ;
Weinstein, MP ;
Fune, J ;
Trippy, CW ;
Masterson, M ;
Reller, LB .
JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (01) :53-58
[7]   Correlation between time to positivity of blood cultures with clinical presentation and outcomes in patients with Klebsiella pneumoniae bacteraemia: prospective cohort study [J].
Liao, C. -H. ;
Lai, C. -C. ;
Hsu, M. -S. ;
Huang, Y. -T. ;
Chu, F. -Y. ;
Hsu, H. -S. ;
Hsueh, P. -R. .
CLINICAL MICROBIOLOGY AND INFECTION, 2009, 15 (12) :1119-1125
[8]   Blood culture-based diagnosis of bacteraemia: state of the art [J].
Opota, O. ;
Croxatto, A. ;
Prod'hom, G. ;
Greub, G. .
CLINICAL MICROBIOLOGY AND INFECTION, 2015, 21 (04) :313-322
[9]   The use of continuous monitoring blood culture systems in the diagnosis of catheter related sepsis [J].
Rogers, MS ;
Oppenheim, BA .
JOURNAL OF CLINICAL PATHOLOGY, 1998, 51 (08) :635-637
[10]  
Shankar-Hari M, 2016, JAMA-J AM MED ASSOC, V315, P775, DOI 10.1001/jama.2016.0289