Translocations, cancer and the puzzle of specificity

被引：82

作者：

Barr, FG ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Sch Med, Philadelphia, PA 19104 USA

来源：

NATURE GENETICS | 1998年 / 19卷 / 02期

关键词：

D O I：

10.1038/475

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The finding of acquired chromosomal translocations that are consistently associated with specific tumour types supports the premise of lineage-specific mechanisms of tumorigenesis. We review the evidence indicating that the specificity of these translocations and the corresponding gene fusions is related to biological constraints at the level of recombination, expression, and protein function. A dynamic relationship between the gene fusion and the cellular environment is proposed in which the environment influences the selection of oncogenic fusions and the oncogenic fusion in turn influences the cellular environment.

引用

页码：121 / 124

页数：4

共 36 条

[1] Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors [J].

Aplan, PD ;

Chervinsky, DS ;

Stanulla, M ;

Burhans, WC .

BLOOD, 1996, 87 (07) :2649-2658

[2] Molecular genetics and pathogenesis of rhabdomyosarcoma [J].

Barr, FG .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 1997, 19 (06) :483-491

[3] A PMLRAR alpha transgene initiates murine acute promyelocytic leukemia [J].

Brown, D ;

Kogan, S ;

Lagasse, E ;

Weissman, I ;

Alcalay, M ;

Pelicci, PG ;

Atwater, S ;

Bishop, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2551-2556

[4] A BCR-ABL(p190) fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product [J].

Castellanos, A ;

Pintado, B ;

Weruaga, E ;

Arevalo, R ;

Lopez, A ;

Orfao, A ;

SanchezGarcia, I .

BLOOD, 1997, 90 (06) :2168-2174

[5] Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11 [J].

Castilla, LH ;

Wijmenga, C ;

Wang, Q ;

Stacy, T ;

Speck, NA ;

Eckhaus, M ;

MarinPadilla, M ;

Collins, FS ;

WynshawBoris, A ;

Liu, PP .

CELL, 1996, 87 (04) :687-696

[6] SEQUENCE AND ANALYSIS OF THE HUMAN ABL GENE, THE BCR GENE, AND REGIONS INVOLVED IN THE PHILADELPHIA CHROMOSOMAL TRANSLOCATION [J].

CHISSOE, SL ;

BODENTEICH, A ;

WANG, YF ;

WANG, YP ;

BURIAN, D ;

CLIFTON, SW ;

CRABTREE, J ;

FREEMAN, A ;

IYER, K ;

LI, JA ;

MA, YC ;

MCLAURY, HJ ;

PAN, HQ ;

SARHAN, OH ;

TOTH, S ;

WANG, ZL ;

ZHANG, GZ ;

HEISTERKAMP, N ;

GROFFEN, J ;

ROE, BA .

GENOMICS, 1995, 27 (01) :67-82

[7] An MII-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes [J].

Corral, J ;

Lavenir, I ;

Impey, H ;

Warren, AJ ;

Forster, A ;

Larson, TA ;

Bell, S ;

McKenzie, ANJ ;

King, G ;

Rabbitts, TH .

CELL, 1996, 85 (06) :853-861

[8] THE CML-SPECIFIC P210 BCR/ABL PROTEIN, UNLIKE V-ABL, DOES NOT TRANSFORM NIH/3T3 FIBROBLASTS [J].

DALEY, GQ ;

MCLAUGHLIN, J ;

WITTE, ON ;

BALTIMORE, D .

SCIENCE, 1987, 237 (4814) :532-535

[9]

DALEY GQ, 1991, ADV CANCER RES, V57, P151

[10] The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice [J].

David, G ;

Terris, B ;

Marchio, A ;

Lavau, C ;

Dejean, A .

ONCOGENE, 1997, 14 (13) :1547-1554

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