Synthesis of spiroindolenine-bearing chroman scaffolds based on a cyclization reaction of para-Quinone methides

被引：4
|
作者：
Qin, Hongmei [1 ]
Xie, Qimei [2 ]
He, Long [1 ,2 ]
机构：
[1] Guiyang Univ, Coll Chem & Mat Engn, Guiyang 550005, Peoples R China
[2] China West Normal Univ, Coll Chem & Chem Engn, Nanchong 637002, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2022年 / 46卷 / 21期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1039/d2nj00936f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient diastereoselective cyclization reaction of orthohydroxyphenyl-substituted para-quinone methides with alpha,beta-unsaturated imines generated in situ from aryl sulfonyl indoles was developed, and afforded spiroindolenine-bearing chroman scaffolds in good to excellent yields (up to 98%) and diastereoselectivities (up to >19 :1 d.r.). This protocol provided an efficient method for constructing spirocyclic compounds incorporating two pharmacophores, namely chroman and spiroindoline.
引用
收藏
页码：9985 / 9988
页数：4
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