Synthesis of spiroindolenine-bearing chroman scaffolds based on a cyclization reaction of para-Quinone methides

被引：4

作者：

Qin, Hongmei ^{[1
]}

Xie, Qimei ^{[2
]}

He, Long ^{[1
,2
]}

机构：

[1] Guiyang Univ, Coll Chem & Mat Engn, Guiyang 550005, Peoples R China

[2] China West Normal Univ, Coll Chem & Chem Engn, Nanchong 637002, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2022年 / 46卷 / 21期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1039/d2nj00936f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient diastereoselective cyclization reaction of orthohydroxyphenyl-substituted para-quinone methides with alpha,beta-unsaturated imines generated in situ from aryl sulfonyl indoles was developed, and afforded spiroindolenine-bearing chroman scaffolds in good to excellent yields (up to 98%) and diastereoselectivities (up to >19 :1 d.r.). This protocol provided an efficient method for constructing spirocyclic compounds incorporating two pharmacophores, namely chroman and spiroindoline.

引用

页码：9985 / 9988

页数：4

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