Class IIa histone deacetylases: regulating the regulators

被引:200
作者
Martin, M. [1 ]
Kettmann, R. [1 ]
Dequiedt, F. [1 ]
机构
[1] FUSAGx, Cellular & Mol Biol Unit, B-5030 Gembloux, Belgium
关键词
14-3-3; acetylation; chromatin; phosphatase; shuttling;
D O I
10.1038/sj.onc.1210613
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the last decade, the identification of enzymes that regulate acetylation of histones and nonhistone proteins has revealed the key role of dynamic acetylation and deacetylation in various cellular processes. Mammalian histone deacetylases ( HDACs), which catalyse the removal of acetyl groups from lysine residues, are grouped into three classes, on the basis of similarity to yeast counterparts. An abundance of experimental evidence has established class IIa HDACs as crucial transcriptional regulators of various developmental and differentiation processes. In the past 5 years, a tremendous effort has been dedicated to characterizing the regulation of these enzymes. In this review, we summarize the latest discoveries in the field and discuss the molecular and structural determinants of class IIa HDACs regulation. Finally, we emphasize that comprehension of the mechanisms underlying class IIa HDAC functions is essential for potential therapeutic applications.
引用
收藏
页码:5450 / 5467
页数:18
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