Chiral separation of some non-steroidal anti-inflammatory drugs on tartardiamide DMB chiral stationary phase by HPLC

被引：15

作者：

Aboul-Enein, HY ^{[1
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Dept Biol & Med Res, Pharmaceut Anal Lab, Riyadh 11211, Saudi Arabia

来源：

JOURNAL OF SEPARATION SCIENCE | 2003年 / 26卷 / 6-7期

关键词：

enantiomers; stereoselectivity; tartardiamide-DMB CSP; non-steroidal anti-inflammatory drugs; chiral recognition; high performance liquid chromatography;

D O I：

10.1002/jssc.200390070

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Selected non-steroidal anti-inflammatory drugs (NSAIDs), namely racemic flurbiprofen, ibuprofen, fenprofen, tiaprofenic acid, ketoprofen, and tolmetin were resolved on Kromasil tartardiamide-DMB chiral stationary phase. Optimum resolution was achieved using a mobile phase consisting of hexane: tert-butyl methyl ether:acetic acid (75 : 25 : 0.1 v/v/v) at flow rate of 1 mL/min. The capacity (k), separation (alpha), and resolution factors (Rs) are reported. The mechanisms of chiral recognition between the analytes and the chiral selector are discussed.

引用

页码：521 / 524

页数：4

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