Maturation of adult peripheral blood CD38+CD4+ T cells demonstrated by cytokine production in response to a superantigen, TSST-1

被引:8
作者
Imanishi, K
Kato, H
Fujii, H
Uchiyama, T
机构
[1] Tokyo Womens Med Univ, Sch Med, Dept Microbiol & Immunol, Shinjuku Ku, Tokyo 1628666, Japan
[2] Tokyo Womens Med Univ, Sch Med, Dept Transfus Med & Cell Proc, Shinjuku Ku, Tokyo 1628666, Japan
关键词
T cells; maturation; superantigen; TSST-1; cytokine;
D O I
10.1016/S0008-8749(03)00111-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
This study looks at immunoincompetent CD4(+) T cells in adult peripheral blood (APB) using cytokine production in response to a superantigen as a measure of function. We compared the function of APB CD38(+)CD4(+) and CD38(-)/(low)CD4(+) T cells to that of cord blood (CB) CD4(+) T cells. APB CD4(+) T cell blasts produce substantial amounts of IL-2 in response to TSST-1 restimulation, while CB CD4(+) T cell blasts produce less. APB CD38(+)CD4(+) T cells produce low levels of IL-4 and IFN-gamma in response to TSST-1, even after activation, while APB CD38(-)/(low)CD4(+) T cells retain their ability to produce high levels of these cytokines despite high CD38 expression. These results suggest that the developmental stage of APB CD38(+)CD4(+) T cells lies between that of CB CD4(+) T cells and APB CD38(-)/(low)CD4(+) T cells and that APB CD38(+)CD45RO(-)CD4(+) T cells gradually cease to express CD38 as they acquire full function. We reconsider CD4(+) cell maturation and response to TSST-1 and discuss the implications of T cell maturity on infectious diseases. (C) 2003 Elsevier Science (USA). All rights reserved.
引用
收藏
页码:89 / 96
页数:8
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