Ilelic Acids A and B, Two Unusual Triterpenes with a Seven-Membered Ring from Ilex latifolia

被引：28
作者：
Wang, Cun-Qin [1 ,3 ]
Wang, Lei [1 ,2 ]
Fan, Chun-Lin [1 ,2 ]
Zhang, Dong-Mei [1 ,2 ]
Huang, Xiao-Jun [1 ,2 ]
Jiang, Ren-Wang [1 ,2 ]
Bai, Liang-Liang [1 ,2 ]
Shi, Jun-Min [1 ,2 ]
Wang, Ying [1 ,2 ]
Ye, Wen-Cai [1 ,2 ,3 ]
机构：
[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
[2] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
[3] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 16期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
SAPONINS; SKELETON;
D O I：
10.1021/ol301745b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two unusual triterpenes, ilelic acids A (1) and B (2), together with their biosynthetic related compounds ilelic acids C (3) and D (4) were isolated from the leaves of Ilex latifolia. Their structures with absolute configurations were elucidated by spectroscopic analysis and modified Mosher's method. The plausible biogenetic pathway of 1 and 2 is proposed. These triterpenes exhibited a potent inhibitory effect on MCF-7 and MDA-MB-231 cells.
引用
收藏
页码：4102 / 4105
页数：4
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