International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

被引：1668

作者：

Arber, Daniel A. ^{[1
]}

Orazi, Attilio ^{[2
]}

Hasserjian, Robert P. ^{[3
]}

Borowitz, Michael J. ^{[4
]}

Calvo, Katherine R. ^{[5
]}

Kvasnicka, Hans-Michael ^{[6
]}

Wang, Sa A. ^{[7
]}

Bagg, Adam ^{[8
]}

Barbui, Tiziano ^{[9
]}

Branford, Susan ^{[10
]}

Bueso-Ramos, Carlos E. ^{[7
]}

Cortes, Jorge E. ^{[11
]}

Dal Cin, Paola ^{[12
]}

DiNardo, Courtney D. ^{[7
]}

Dombret, Herve ^{[13
]}

Duncavage, Eric J. ^{[14
]}

Ebert, Benjamin L. ^{[15
]}

Estey, Elihu H. ^{[16
]}

Facchetti, Fabio ^{[17
]}

Foucar, Kathryn ^{[18
]}

Gangat, Naseema ^{[19
]}

Gianelli, Umberto ^{[20
]}

Godley, Lucy A. ^{[1
]}

Gokbuget, Nicola ^{[21
]}

Gotlib, Jason ^{[22
]}

Hellstrom-Lindberg, Eva ^{[23
]}

Hobbs, Gabriela S. ^{[3
]}

Hoffman, Ronald ^{[24
]}

Jabbour, Elias J. ^{[7
]}

Kiladjian, Jean-Jacques ^{[13
]}

Larson, Richard A. ^{[1
]}

Le Beau, Michelle M. ^{[1
]}

Loh, Mignon L. -C. ^{[25
]}

Lowenberg, Bob ^{[26
]}

Macintyre, Elizabeth ^{[27
]}

Malcovati, Luca ^{[28
]}

Mullighan, Charles G. ^{[29
]}

Niemeyer, Charlotte ^{[30
]}

Odenike, Olatoyosi M.

Ogawa, Seishi ^{[31
]}

Orfao, Alberto ^{[32
]}

Papaemmanuil, Elli ^{[33
]}

Passamonti, Francesco

Porkka, Kimmo ^{[34
]}

Pui, Ching-Hon ^{[29
]}

Radich, Jerald P. ^{[35
]}

Reiter, Andreas ^{[36
]}

Rozman, Maria ^{[37
]}

Rudelius, Martina ^{[38
]}

Savona, Michael R. ^{[39
]}

机构：

[1] Univ Chicago, Chicago, IL 60637 USA

[2] Texas Tech Univ, Hlth Sci Ctr El Paso, El Paso, TX USA

[3] Massachusetts Gen Hosp, Boston, MA 02114 USA

[4] Johns Hopkins Univ, Baltimore, MD USA

[5] NIH, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA

[6] Helios Univ Klinikum Wuppertal, Wuppertal, Germany

[7] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[8] Univ Penn, Philadelphia, PA 19104 USA

[9] Papa Giovanni XXIII Hosp, Clin Res Fdn, Bergamo, Italy

[10] Ctr Canc Biol, Adelaide, SA, Australia

[11] Georgia Canc Ctr, Augusta, GA USA

[12] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[13] Univ Paris Cite, Hop St Louis, AP HP, Paris, France

[14] Washington Univ, St Louis, MO 63110 USA

[15] Dana Farber Canc Inst, Boston, MA 02115 USA

[16] Univ Washington, Seattle, WA 98195 USA

[17] Univ Brescia, Sch Med, Brescia, Italy

[18] Univ New Mexico, Albuquerque, NM 87131 USA

[19] Mayo Clin, Rochester, MN USA

[20] Univ Milan, Milan, Italy

[21] Goethe Univ, Frankfurt, Germany

[22] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[23] Karolinska Inst, Solna, Sweden

[24] Mt Sinai Med Ctr, New York, NY 10029 USA

[25] Seattle Childrens Hosp, Seattle, WA USA

[26] Erasmus MC, Rotterdam, Netherlands

[27] Univ Paris Cite, Paris, France

[28] Univ Pavia, Pavia, Italy

[29] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA

[30] Univ Freiburg, Med Ctr, Freiburg, Germany

[31] Kyoto Univ, Kyoto, Japan

[32] Univ Salamanca, Salamanca, Spain

[33] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[34] Univ Helsinki, Comprehens Canc Ctr, Cent Hosp, Helsinki, Finland

[35] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[36] Univ Hosp Mannheim, Mannheim, Germany

[37] Univ Barcelona, Barcelona, Spain

[38] Ludwig Maximilians Univ Munchen, Munich, Germany

[39] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA

[40] Karmanos Canc Inst, Detroit, MI USA

[41] Albert Ludwigs Univ Freiburg, Freiburg, Germany

[42] Boston Childrens Canc & Blood Disorders Ctr, Boston, MA USA

[43] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[44] Lurie Childrens Hosp, Chicago, IL USA

[45] Univ Cologne, Cologne, Germany

[46] Natl Taiwan Univ Hosp, Taipei, Taiwan

[47] Med Univ Basel, Basel, Switzerland

[48] Univ Florence, Florence, Italy

[49] AOU Careggi, Florence, Italy

[50] Univ Oxford, Oxford, England

来源：

BLOOD | 2022年 / 140卷 / 11期

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC MYELOMONOCYTIC LEUKEMIA; WORLD-HEALTH-ORGANIZATION; CHRONIC EOSINOPHILIC LEUKEMIA; SYSTEMIC MASTOCYTOSIS SM; PROGNOSTIC SCORING SYSTEM; MINIMAL RESIDUAL DISEASE; IN-SITU HYBRIDIZATION; MYELODYSPLASTIC SYNDROME; REFRACTORY CYTOPENIA;

D O I：

10.1182/blood.2022015850

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The classification of myeloid neoplasms and acute leukemias was last updated in 2016 within a collaboration between the World Health Organization (WHO), the Society for Hematopathology, and the European Association for Haematopathology. This collaboration was primarily based on input from a clinical advisory committees (CACs) composed of pathologists, hematologists, oncologists, geneticists, and bioin-formaticians from around the world. The recent advances in our understanding of the biology of hematologic malignancies, the experience with the use of the 2016 WHO classification in clinical practice, and the results of clinical trials have indicated the need for further revising and updating the classification. As a continuation of this CAC-based process, the authors, a group with expertise in the clinical, pathologic, and genetic aspects of these disorders, developed the International Consensus Classification (ICC) of myeloid neoplasms and acute leukemias. Using a multiparameter approach, the main objective of the consensus process was the definition of real disease entities, including the introduction of new entities and refined criteria for existing diagnostic categories, based on accumulated data. The ICC is aimed at facilitating diagnosis and prognostication of these neoplasms, improving treatment of affected patients, and allowing the design of innovative clinical trials.

引用

页码：1200 / 1228

页数：29

共 263 条

[11] T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness [J].

Bardelli, Valentina ;

Arniani, Silvia ;

Pierini, Valentina ;

Di Giacomo, Danika ;

Pierini, Tiziana ;

Gorello, Paolo ;

Mecucci, Cristina ;

La Starza, Roberta .

GENES, 2021, 12 (08)

[12] PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia [J].

Bastian, Lorenz ;

Schroeder, Michael P. ;

Eckert, Cornelia ;

Schlee, Cornelia ;

Tanchez, Jutta Ortiz ;

Kaempf, Sebastian ;

Wagner, Dimitrios L. ;

Schulze, Veronika ;

Isaakidis, Konstandina ;

Lazaro-Navarro, Juan ;

Haenzelmann, Sonja ;

James, Alva Rani ;

Ekici, Arif ;

Burmeister, Thomas ;

Schwartz, Stefan ;

Schrappe, Martin ;

Horstmann, Martin ;

Vosberg, Sebastian ;

Krebs, Stefan ;

Blum, Helmut ;

Hecht, Jochen ;

Greif, Philipp A. ;

Rieger, Michael A. ;

Brueggemann, Monika ;

Goekbuget, Nicola ;

Neumann, Martin ;

Baldus, Claudia D. .

LEUKEMIA, 2019, 33 (08) :1895-1909

[13] Morphological differentiation of severe aplastic anaemia from hypocellular refractory cytopenia of childhood: reproducibility of histopathological diagnostic criteria [J].

Baumann, Irith ;

Fuehrer, Monika ;

Behrendt, Sonja ;

Campr, Vit ;

Csomor, Judit ;

Furlan, Ingrid ;

de Haas, Valerie ;

Kerndrup, Gitte ;

Leguit, Roos J. ;

De Paepe, Pascale ;

Noellke, Peter ;

Niemeyer, Charlotte ;

Schwarz, Stephan .

HISTOPATHOLOGY, 2012, 61 (01) :10-17

[14] Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease [J].

Beck, David B. ;

Ferrada, Marcela A. ;

Sikora, Keith A. ;

Ombrello, Amanda K. ;

Collins, Jason C. ;

Pei, Wuhong ;

Balanda, Nicholas ;

Ross, Daron L. ;

Ospina Cardona, Daniela ;

Wu, Zhijie ;

Patel, Bhavisha ;

Manthiram, Kalpana ;

Groarke, Emma M. ;

Gutierrez-Rodrigues, Fernanda ;

Hoffmann, Patrycja ;

Rosenzweig, Sofia ;

Nakabo, Shuichiro ;

Dillon, Laura W. ;

Hourigan, Christopher S. ;

Tsai, Wanxia L. ;

Gupta, Sarthak ;

Carmona-Rivera, Carmelo ;

Asmar, Anthony J. ;

Xu, Lisha ;

Oda, Hirotsugu ;

Goodspeed, Wendy ;

Barron, Karyl S. ;

Nehrebecky, Michele ;

Jones, Anne ;

Laird, Ryan S. ;

Deuitch, Natalie ;

Rowczenio, Dorota ;

Rominger, Emily ;

Wells, Kristina V. ;

Lee, Chyi-Chia R. ;

Wang, Weixin ;

Trick, Megan ;

Mullikin, James ;

Wigerblad, Gustaf ;

Brooks, Stephen ;

Dell'Orso, Stefania ;

Deng, Zuoming ;

Chae, Jae J. ;

Dulau-Florea, Alina ;

Malicdan, May C. V. ;

Novacic, Danica ;

Colbert, Robert A. ;

Kaplan, Mariana J. ;

Gadina, Massimo ;

Savic, Sinisa .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) :2628-2638

[15] Implications ofTP53allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes [J].

Bernard, Elsa ;

Nannya, Yasuhito ;

Hasserjian, Robert P. ;

Devlin, Sean M. ;

Tuechler, Heinz ;

Medina-Martinez, Juan S. ;

Yoshizato, Tetsuichi ;

Shiozawa, Yusuke ;

Saiki, Ryunosuke ;

Malcovati, Luca ;

Levine, Max F. ;

Arango, Juan E. ;

Zhou, Yangyu ;

Sole, Francesc ;

Cargo, Catherine A. ;

Haase, Detlef ;

Creignou, Maria ;

Germing, Ulrich ;

Zhang, Yanming ;

Gundem, Gunes ;

Sarian, Araxe ;

van de Loosdrecht, Arjan A. ;

Jadersten, Martin ;

Tobiasson, Magnus ;

Kosmider, Olivier ;

Follo, Matilde Y. ;

Thol, Felicitas ;

Pinheiro, Ronald F. ;

Santini, Valeria ;

Kotsianidis, Ioannis ;

Boultwood, Jacqueline ;

Santos, Fabio P. S. ;

Schanz, Julie ;

Kasahara, Senji ;

Ishikawa, Takayuki ;

Tsurumi, Hisashi ;

Takaori-Kondo, Akifumi ;

Kiguchi, Toru ;

Polprasert, Chantana ;

Bennett, John M. ;

Klimek, Virginia M. ;

Savona, Michael R. ;

Belickova, Monika ;

Ganster, Christina ;

Palomo, Laura ;

Sanz, Guillermo ;

Ades, Lionel ;

Della Porta, Matteo Giovanni ;

Smith, Alexandra G. ;

Werner, Yesenia .

NATURE MEDICINE, 2020, 26 (10) :1549-+

[16] Classification and Personalized Prognostic Assessment on the Basis of Clinical and Genomic Features in Myelodysplastic Syndromes [J].

Bersanelli, Matteo ;

Travaglino, Erica ;

Meggendorfer, Manja ;

Matteuzzi, Tommaso ;

Sala, Claudia ;

Mosca, Ettore ;

Chiereghin, Chiara ;

Di Nanni, Noemi ;

Gnocchi, Matteo ;

Zampini, Matteo ;

Rossi, Marianna ;

Maggioni, Giulia ;

Termanini, Alberto ;

Angelucci, Emanuele ;

Bernardi, Massimo ;

Borin, Lorenza ;

Bruno, Benedetto ;

Bonifazi, Francesca ;

Santini, Valeria ;

Bacigalupo, Andrea ;

Voso, Maria Teresa ;

Oliva, Esther ;

Riva, Marta ;

Ubezio, Marta ;

Morabito, Lucio ;

Campagna, Alessia ;

Saitta, Claudia ;

Savevski, Victor ;

Giampieri, Enrico ;

Remondini, Daniel ;

Passamonti, Francesco ;

Ciceri, Fabio ;

Bolli, Niccolo ;

Rambaldi, Alessandro ;

Kern, Wolfgang ;

Kordasti, Shahram ;

Sole, Francesc ;

Palomo, Laura ;

Sanz, Guillermo ;

Santoro, Armando ;

Platzbecker, Uwe ;

Fenaux, Pierre ;

Milanesi, Luciano ;

Haferlach, Torsten ;

Castellani, Gastone ;

Della Porta, Matteo G. .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (11) :1223-+

[17] Mutational Landscape of TdT+ Large B-cell Lymphomas Supports Their Distinction From B-lymphoblastic Neoplasms A Multiparameter Study of a Rare and Aggressive Entity [J].

Bhavsar, Shweta ;

Liu, Yen-Chun ;

Gibson, Sarah E. ;

Moore, Erika M. ;

Swerdlow, Steven H. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2022, 46 (01) :71-82

[18] Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study [J].

Boer, Judith M. ;

Valsecchi, Maria Grazia ;

Hormann, Femke M. ;

Antic, Zeljko ;

Zaliova, Marketa ;

Schwab, Claire ;

Cazzaniga, Giovanni ;

Arfeuille, Chloe ;

Cave, Helene ;

Attarbaschi, Andishe ;

Strehl, Sabine ;

Escherich, Gabriele ;

Imamura, Toshihiko ;

Ohki, Kentaro ;

Grueber, Tanja A. ;

Sutton, Rosemary ;

Pastorczak, Agata ;

Lammens, Tim ;

Lambert, Frederic ;

Li, Chi Kong ;

Carrillo de Santa Pau, Enrique ;

Hoffmann, Steve ;

Moericke, Anja ;

Harrison, Christine J. ;

Den Boer, Monique L. ;

De Lorenzo, Paola ;

Stam, Ronald W. ;

Bergmann, Anke K. ;

Pieters, Rob .

LEUKEMIA, 2021, 35 (10) :2978-2982

[19] Development of monocytosis in patients with primary myelofibrosis indicates an accelerated phase of the disease [J].

Boiocchi, Leonardo ;

Espinal-Witter, Rosanny ;

Geyer, Julia Turbiner ;

Steinhilber, Julia ;

Bonzheim, Irina ;

Knowles, Daniel M. ;

Fend, Falko ;

Orazi, Attilio .

MODERN PATHOLOGY, 2013, 26 (02) :204-212

[20] Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers [J].

Bougeard, Gaelle ;

Renaux-Petel, Mariette ;

Flaman, Jean-Michel ;

Charbonnier, Camille ;

Fermey, Pierre ;

Belotti, Muriel ;

Gauthier-Villars, Marion ;

Stoppa-Lyonnet, Dominique ;

Consolino, Emilie ;

Brugieres, Laurence ;

Caron, Olivier ;

Benusiglio, Patrick R. ;

Bressac-de Paillerets, Brigitte ;

Bonadona, Valerie ;

Bonaiti-Pellie, Catherine ;

Tinat, Julie ;

Baert-Desurmont, Stephanie ;

Frebourg, Thierry .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (21) :2345-U33

← 1 2 3 4 5 6 7 8 9 10 →