Cell encapsulation: Promise and progress

被引：469

作者：

Orive, Gorka ^{[1
]}

Maria Hernandez, Rosa ^{[1
]}

Gascon, Alicia R. ^{[1
]}

Calafiore, Riccardo ^{[2
]}

Chang, Thomas M. S. ^{[3
]}

De Vos, Paul ^{[4
]}

Hortelano, Gonzalo ^{[5
,6
]}

Hunkeler, David ^{[7
]}

Lacik, Igor ^{[8
]}

Shapiro, A. M. James ^{[9
]}

Luis Pedraz, Jose ^{[1
]}

机构：

[1] Univ Basque Country, Fac Pharm, Lab Pharm & Pharmaceut Technol, Vitoria, Spain

[2] Univ Perugia, Dept Internal Med, I-06100 Perugia, Italy

[3] McGill Univ, Fac Med, Artificial Cells & Organs Res Ctr, Montreal, PQ, Canada

[4] Dept Pathol & Lab Med, Groningen, Netherlands

[5] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada

[6] Canadian Blood Serv, Hamilton, ON, Canada

[7] AQUA TECH Specialties SA, Geneva, Switzerland

[8] Slovak Acad Sci, Inst Polymer, Dept Special Polymers & Biopolymers, Bratislava, Slovakia

[9] Univ Alberta, Clin Islet Transplant Program, Edmonton, AB, Canada

来源：

NATURE MEDICINE | 2003年 / 9卷 / 01期

关键词：

D O I：

10.1038/nm0103-104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In cell encapsulation, transplanted cells are protected from immune rejection by an artificial, semipermeable membrane, potentially allowing transplantation (allo-or xenotransplantation) without the need for immunosuppression. Yet, despite some promising results in animal studies, the field has not lived up to expectations, and clinical products based on encapsulated cell technology continue to elude the scientific community. This commentary discusses the reasons for this, summarizes recent progress in the field and outlines what is needed to bring this technology closer to clinical application.

引用

页码：104 / 107

页数：4

共 38 条

[1] Cellular xenotransplantation [J].