The neurodevelopmental origins of suicidal behavior

被引：206

作者：

Turecki, Gustavo ^{[1
]}

Ernst, Carl ^{[1
]}

Jollant, Fabrice ^{[1
]}

Labonte, Benoit ^{[1
]}

Mechawar, Naguib ^{[1
]}

机构：

[1] McGill Univ, McGill Grp Suicide Studies, Dept Psychiat, Montreal, PQ, Canada

来源：

TRENDS IN NEUROSCIENCES | 2012年 / 35卷 / 01期

关键词：

CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS; DEXAMETHASONE SUPPRESSION TEST; CHILDHOOD SEXUAL-ABUSE; GRAY-MATTER VOLUME; NEUROTROPHIC FACTOR; DNA METHYLATION; PERSONALITY-TRAITS; GENE-EXPRESSION; FRONTAL-CORTEX;

D O I：

10.1016/j.tins.2011.11.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Suicide and related behaviors are complex phenomena associated with different risk factors. Although most individuals who display suicidal behavior do not have a history of early-life adversity, a significant minority does. Recent animal and human data have suggested that early-life adversity leads to epigenetic regulation of genes involved in stress-response systems. Here, we review this evidence and suggest that early-life adversity increases risk of suicide in susceptible individuals by influencing the development of stable emotional, behavioral and cognitive phenotypes that are likely to result from the epigenetic regulation of the hypothalamic pituitary adrenal axis and other systems involved in responses to stress.

引用

页码：14 / 23

页数：10

共 130 条

[1] Childhood trauma and cognitive function in first-episode affective and non-affective psychosis [J].

Aas, Monica ;

Dazzan, Paola ;

Fisher, Helen L. ;

Morgan, Craig ;

Morgan, Kevin ;

Reichenberg, Abraham ;

Zanelli, Jolanta ;

Fearon, Paul ;

Jones, Peter B. ;

Murray, Robin M. ;

Pariante, Carmine M. .

SCHIZOPHRENIA RESEARCH, 2011, 129 (01) :12-19

[2] Left orbitofrontal and superior temporal gyrus structural changes associated to suicidal behavior in patients with schizophrenia [J].

Aguilar, E. J. ;

Garcia-Marti, G. ;

Marti-Bonmati, L. ;

Lull, J. J. ;

Moratal, D. ;

Escarti, M. J. ;

Robles, M. ;

Gonzalez, J. C. ;

Guillamon, M. I. ;

Sanjuan, J. .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2008, 32 (07) :1673-1676

[3] Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed [J].

Alt, Simone R. ;

Turner, Jonathan D. ;

Klok, Melanie D. ;

Meijer, Onno C. ;

Lakke, Egbert A. J. F. ;

DeRijk, Roel H. ;

Muller, Claude P. .

PSYCHONEUROENDOCRINOLOGY, 2010, 35 (04) :544-556

[4] THE ZURICH STUDY .15. SUICIDE ATTEMPTS IN A COHORT FROM AGE 20 TO 30 [J].

ANGST, J ;

DEGONDA, M ;

ERNST, C .

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 1992, 242 (2-3) :135-141

[5]

[Anonymous], POPUL DEV REV

[6]

[Anonymous], CIBA FDN S

[7]

[Anonymous], BMC PSYCHIAT

[8]

[Anonymous], ARCH GEN PS IN PRESS

[9] Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder [J].

Aston, C ;

Jiang, L ;

Sokolov, BP .

MOLECULAR PSYCHIATRY, 2005, 10 (03) :309-322

[10] Increased corticotropin-releasing hormone immunoreactivity in monoamine-containing pontine nuclei of depressed suicide men [J].

Austin, MC ;

Janosky, JE ;

Murphy, HA .

MOLECULAR PSYCHIATRY, 2003, 8 (03) :324-332

← 1 2 3 4 5 6 7 8 9 10 →