Development of a rapid test kit for SARS-CoV-2: an example of product design

被引：17

作者：

Cui, Zhanfeng ^{[1
,2
,3
]}

Chang, Hong ^{[1
]}

Wang, Hui ^{[1
]}

Lim, Boon ^{[2
]}

Hsu, Chia-Chen ^{[2
,3
]}

Yu, Yejiong ^{[2
,3
]}

Jia, Huidong ^{[1
]}

Wang, Yun ^{[1
]}

Zeng, Yida ^{[1
]}

Ji, Mengmeng ^{[1
]}

Liu, Weizhi ^{[1
]}

Inverarity, Catriona ^{[1
]}

Huang, Wei E. ^{[1
,2
]}

机构：

[1] Univ Oxford, Oxford Suzhou Ctr Adv Res OSCAR, Suzhou, Jiangsu, Peoples R China

[2] Univ Oxford, Dept Engn Sci, Parks Rd, Oxford OX1 3PJ, England

[3] Univ Oxford, Inst Biomed Engn, Dept Engn Sci, Oxford OX3 7DQ, England

来源：

BIO-DESIGN AND MANUFACTURING | 2020年 / 3卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

COVID-19; Antigen detection; Rapid test; Product design; SAR-Cov-2; RT-LAMP;

D O I：

10.1007/s42242-020-00075-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We present an example of applying 'need-driven' product design principle to the development of a rapid test kit to detect SARS-COV-2 (COVID-19). The tests are intended for use in the field and, longer term, for home use. They detect whether a subject is currently infected with the virus and is infectious. The urgent need for large numbers of tests in field setting imposes constraints such as short test time and lack of access to specialist equipment, laboratories and skilled technicians to perform the test and interpret results. To meet these needs, an antigen test based on RT-LAMP with colorimetric readout was chosen. Direct use of swab sample with no RNA extraction was explored. After extensive experimental study (reported elsewhere), a rapid test kit has been fabricated to satisfy all design criteria.

引用

页码：83 / 86

页数：4

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