Asbestos induces inflammatory cytokines in the lung through redox sensitive transcription factors

被引：39
|
作者：
Luster, MI [1 ]
Simeonova, PP [1 ]
机构：
[1] NIOSH, Hlth Effects Lab Div, Toxicol & Mol Biol Branch, Morgantown, WV 26505 USA
来源：
TOXICOLOGY LETTERS | 1998年 / 103卷
关键词：
asbestos; cytokines; inflammation; lung;
D O I：
10.1016/S0378-4274(98)00321-X
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Studies are summarized demonstrating that the inflammatory cytokines, interleukin IL-6 and IL-8, play a direct role in asbestos lung diseases and are produced by lung epithelial cells in direct response to the fibers. This response is controlled by changes in the cellular oxidative/state induced by iron present in the fiber through Fenton-type chemistry. As a result of this oxidative stress, the redox sensitive transcription factors, NF-kappa B and NF-IL-6, which help regulate cytokine gene expression, are activated. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：271 / 275
页数：5
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