Asbestos induces inflammatory cytokines in the lung through redox sensitive transcription factors

被引：39

作者：

Luster, MI ^{[1
]}

Simeonova, PP ^{[1
]}

机构：

[1] NIOSH, Hlth Effects Lab Div, Toxicol & Mol Biol Branch, Morgantown, WV 26505 USA

来源：

TOXICOLOGY LETTERS | 1998年 / 103卷

关键词：

asbestos; cytokines; inflammation; lung;

D O I：

10.1016/S0378-4274(98)00321-X

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Studies are summarized demonstrating that the inflammatory cytokines, interleukin IL-6 and IL-8, play a direct role in asbestos lung diseases and are produced by lung epithelial cells in direct response to the fibers. This response is controlled by changes in the cellular oxidative/state induced by iron present in the fiber through Fenton-type chemistry. As a result of this oxidative stress, the redox sensitive transcription factors, NF-kappa B and NF-IL-6, which help regulate cytokine gene expression, are activated. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：271 / 275

页数：5

共 36 条

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