Maximum and Time-Dependent Body Mass Index and Breast Cancer Incidence Among Postmenopausal Women in the Black Women's Health Study

被引:5
作者
Gathirua-Mwangi, Wambui G. [2 ]
Palmer, Julie R. [1 ,3 ]
Champion, Victoria [4 ]
Castro-Webb, Nelsy [1 ]
Stokes, Andrew C. [5 ]
Adams-Campbell, Lucile [6 ]
Marley, Andrew R. [7 ]
Forman, Michele R. [8 ]
Rosenberg, Lynn [1 ]
Bertrand, Kimberly A. [1 ,3 ]
机构
[1] Boston Univ, Slone Epidemiol Ctr, 72 East Concord St,L-7, Boston, MA 02118 USA
[2] Eli Lilly & Co, Indianapolis, IN 46285 USA
[3] Boston Univ, Sch Med, Boston, MA 02118 USA
[4] Indiana Univ, Sch Nursing, Indianapolis, IN USA
[5] Boston Univ, Dept Global Hlth, Sch Publ Hlth, Boston, MA 02118 USA
[6] Georgetown Univ, Georgetown Lombardi Canc Ctr, Med Ctr, Washington, DC USA
[7] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA
[8] Purdue Univ, Dept Nutr Sci, Coll Hlth & Human Sci, W Lafayette, PA USA
关键词
African Americans; Black race; body mass index; breast cancer; lagged analysis; obesity; ADULT WEIGHT CHANGE; FAT DISTRIBUTION; RISK; OBESITY; SIZE; GAIN; INFLAMMATION; ACCURACY; SUBTYPES; HISTORY;
D O I
10.1093/aje/kwac004
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
While excess weight is an established risk factor for postmenopausal breast cancer, consideration of maximum body mass index (maxBMI; BMI is calculated as weight (kg)/height (m)(2)) or BMI at a point in time relevant for breast carcinogenesis may offer new insights. We prospectively evaluated maxBMI and time-dependent BMI in relation to breast cancer incidence among 31,028 postmenopausal women in the Black Women's Health Study. During 1995-2015, a total of 1,384 diagnoses occurred, including 787 estrogen-receptor (ER)-positive (ER+) cases and 310 ER-negative (ER-) cases. BMI was assessed at baseline and 2, 4, 6, and 8 years before diagnosis. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Compared with women with BMI <25, those with BMI >= 35 had increased risk of ER+ breast cancer but not ER- breast cancer. For BMI assessed 2 years before diagnosis, the HRs for ER+ breast cancer associated with maxBMI >= 35 and time-dependent BMI >= 35 were 1.42 (95% confidence interval (CI): 1.10, 1.84) and 1.63 (95% CI: 1.25, 2.13), respectively. The corresponding HR for time-dependent BMI assessed 6 years before diagnosis was 1.95 (95% CI: 1.45, 2.62). These findings suggest strong associations of BMI with risk of ER+ breast cancer in postmenopausal women, regardless of timing of BMI assessment.
引用
收藏
页码:646 / 654
页数:9
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