Reciprocal regulation of the neural and innate immune systems

被引：644

作者：

Irwin, Michael R. ^{[1
]}

Cole, Steven W. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, Semel Inst Neurosci, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Med, Div Haematol Oncol, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, UCLA Mol Biol Inst, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 09期

关键词：

BREAST-CANCER SURVIVORS; C-REACTIVE PROTEIN; PSYCHOLOGICAL STRESS; INFLAMMATORY BIOMARKERS; RHEUMATOID-ARTHRITIS; SLEEP-DEPRIVATION; PERIPHERAL-BLOOD; MAJOR DEPRESSION; INTERFERON-ALPHA; SOCIAL STRESS;

D O I：

10.1038/nri3042

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate immune responses are regulated by microorganisms and cell death, as well as by a third class of stress signal from the nervous and endocrine systems. The innate immune system also feeds back, through the production of cytokines, to regulate the function of the central nervous system (CNS), and this has effects on behaviour. These signals provide an extrinsic regulatory circuit that links physiological, social and environmental conditions, as perceived by the CNS, with transcriptional 'decision-making' in leukocytes. CNS-mediated regulation of innate immune responses optimizes total organism fitness and provides new opportunities for therapeutic control of chronic infectious, inflammatory and neuropsychiatric diseases.

引用

页码：625 / 632

页数：9

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