Therapeutic Targets and Emerging Treatments in Advanced Chondrosarcoma

被引：27
|
作者：
Miwa, Shinji [1 ]
Yamamoto, Norio [1 ]
Hayashi, Katsuhiro [1 ]
Takeuchi, Akihiko [1 ]
Igarashi, Kentaro [1 ]
Tsuchiya, Hiroyuki [1 ]
机构：
[1] Kanazawa Univ, Grad Sch Med Sci, Dept Orthoped Surg, Kanazawa, Ishikawa 9208640, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 03期
关键词：
chondrosarcoma; chemotherapy; immunotherapy; therapeutic target; EPITHELIAL-MESENCHYMAL TRANSITION; EXPRESSION; MUTATIONS; BONE; SARCOMA; IDH1; MULTICENTER; DOXORUBICIN; ACTIVATION; BEHAVIOR;
D O I：
10.3390/ijms23031096
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Simple Summary Chondrosarcomas develop chemoresistance to standard anticancer drugs, making it difficult to control unresectable or metastatic chondrosarcomas. To improve the clinical outcomes of chondrosarcoma, new treatment approaches, such as molecule-targeting agents and immunotherapy, are needed. Recent research has revealed promising biomarkers and therapeutic targets for chondrosarcoma. In addition, several molecule-targeting agents have shown favorable antitumor activities in several clinical studies in patients with advanced sarcomas, including chondrosarcoma. This review summarizes recent basic studies on biomarkers and therapeutic targets and recent clinical studies on treating chondrosarcomas. Due to resistance to standard anticancer agents, it is difficult to control the disease progression in patients with metastatic or unresectable chondrosarcoma. Novel therapeutic approaches, such as molecule-targeting drugs and immunotherapy, are required to improve clinical outcomes in patients with advanced chondrosarcoma. Recent studies have suggested several promising biomarkers and therapeutic targets for chondrosarcoma, including IDH1/2 and COL2A1. Several molecule-targeting agents and immunotherapies have shown favorable antitumor activity in clinical studies in patients with advanced chondrosarcomas. This review summarizes recent basic studies on biomarkers and molecular targets and recent clinical studies on the treatment of chondrosarcomas.
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页数：12
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