Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea

被引：47

作者：

Zhang, Tao ^{[1
,2
]}

Cheng, Liang ^{[1
]}

Hameed, Shahid ^{[1
,3
]}

Liu, Li ^{[1
]}

Wang, Dong ^{[1
]}

Chen, Yong-Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci BNLMS, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 23期

基金：

中国国家自然科学基金;

关键词：

IONIC LIQUIDS; CONJUGATE ADDITION; BIFUNCTIONAL ORGANOCATALYSTS; QUATERNARY STEREOCENTERS; ASYMMETRIC-SYNTHESIS; NITROALKENES; OXINDOLES; MALONATE; DERIVATIVES; CHALCONES;

D O I：

10.1039/c1cc10880h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly enantioselective Michael addition of 2-oxindoles (1) to vinyl selenone (2) in RTILs catalyzed by a Cinchona alkaloid-based thiourea has been developed in high yields (80-91%) with excellent enantioselectivities (up to 95% ee).

引用

收藏

页码：6644 / 6646

页数：3

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