Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea

被引：46
|
作者：
Zhang, Tao [1 ,2 ]
Cheng, Liang [1 ]
Hameed, Shahid [1 ,3 ]
Liu, Li [1 ]
Wang, Dong [1 ]
Chen, Yong-Jun [1 ]
机构：
[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci BNLMS, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
[3] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 23期
基金：
中国国家自然科学基金;
关键词：
IONIC LIQUIDS; CONJUGATE ADDITION; BIFUNCTIONAL ORGANOCATALYSTS; QUATERNARY STEREOCENTERS; ASYMMETRIC-SYNTHESIS; NITROALKENES; OXINDOLES; MALONATE; DERIVATIVES; CHALCONES;
D O I：
10.1039/c1cc10880h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly enantioselective Michael addition of 2-oxindoles (1) to vinyl selenone (2) in RTILs catalyzed by a Cinchona alkaloid-based thiourea has been developed in high yields (80-91%) with excellent enantioselectivities (up to 95% ee).
引用
收藏
页码：6644 / 6646
页数：3
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