Dynamics of a lipid bilayer induced by electric fields

被引：8

作者：

Venturini, Alessandro ^{[1
]}

Zerbetto, Francesco ^{[2
]}

机构：

[1] Natl Res Council Italy, Inst Organ Synth & Photoreact, I-40129 Bologna, Italy

[2] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2011年 / 13卷 / 20期

关键词：

PARTICLE MESH EWALD; MOLECULAR-DYNAMICS; MEMBRANE ELECTROPORATION; PHOSPHOLIPID-BILAYERS; IN-SILICO; WATER; TRANSLOCATION; SIMULATIONS; PORES; CELLS;

D O I：

10.1039/c1cp20322c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The dynamics of a lipid bilayer of 1-palmitoyl-2-oleoyl-glycero-3-phospho-ethanolamine, POPE, is investigated under the effect of two electric field intensities. The box of 720 lipids and 13 458 water molecules-plus boundary conditions-undergoes similar re-organizational dynamics in the presence of fields of 0.35 V nm(-1) and 0.5 V nm(-1). Water fingers form followed by some lipid translocation from one layer to the other. The re-organization kinetics is of the second order and is roughly 5 times faster at the higher field. The translocations may occur also upon field switch off, provided that their duration was sufficiently long. Driving few lipid translocations by a macroscopic tool, such as the electric field, appears possible.

引用

页码：9216 / 9222

页数：7

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