Fluorescence Turn On by Cholate Aggregates

被引：22

作者：

Baldridge, Anthony ^{[1
]}

Amador, Adrian ^{[1
]}

Tolbert, Laren M. ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

来源：

LANGMUIR | 2011年 / 27卷 / 07期

基金：

美国国家科学基金会;

关键词：

BILE-SALT MICELLES; SODIUM CHOLATE; STRUCTURAL BASIS; IMIDATE YLIDES; PROTEIN; SOLUBILIZATION; CHROMOPHORE; BINDING; MODEL; SIZE;

D O I：

10.1021/la2003244

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bile salts, including sodium cholate (NaCh), are amphiphilic molecules with a concave hydrophilic side and a convex hydrophobic side. By forming aggregates in aqueous solution, these natural surfactants fulfill vital biological roles in the solubilization of cholesterol, lipids, and fat-soluble vitamins and thus are involved in the transport and absorption of important biological molecules. Following our success with the encapsulation of fluorescent protein chromophore (FP) analogs by synthetic hydrophobic and hydrophilic hosts, based upon substitution patterns, we now report the binding and turn on of other analogs by bile salt aggregates, observations which may lead to new tools for studying trafficking in these important systems.

引用

页码：3271 / 3274

页数：4

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