Actin is oxidized during myocardial ischemia

被引：75

作者：

Powell, SR ^{[1
]}

Gurzenda, EM ^{[1
]}

Wahezi, SE ^{[1
]}

机构：

[1] Winthrop Univ Hosp, Dept Obstet & Gynecol, Maternal Fetal Med Res Lab, Mineola, NY 11501 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2001年 / 30卷 / 10期

关键词：

actin; protein oxidation; protein carbonyls; myocardial ischemia; free radicals;

D O I：

10.1016/S0891-5849(01)00514-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exposure of isolated rat hearts to 30 min global ischemia followed by 60 min reperfusion resulted in a significant 80% increase (p <.05) in actin content of carbonyl groups, which was associated with significant depression (p <.05) of postischemic contractile function. This result supports the hypothesis that one mechanism of postischemic contractile dysfunction may be oxidation of contractile proteins. (C) 2001 Elsevier Science Inc.

引用

页码：1171 / 1176

页数：6

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