The yeast Mediator complex and its regulation

被引:158
作者
Björklund, S [1 ]
Gustafsson, CM
机构
[1] Umea Univ, Dept Med Biochem, S-90187 Umea, Sweden
[2] Karolinska Inst, Dept Med Nutr, S-14186 Huddinge, Sweden
关键词
D O I
10.1016/j.tibs.2005.03.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Mediator complex acts as a bridge, conveying regulatory information from enhancers and other control elements to the basal RNA polymerase II transcription machinery. Mediator is required for the regulated transcription of nearly all RNA polymerase II-dependent genes in Saccharomyces cerevisiae, and post-translational modifications of specific Mediator subunits can affect global patterns of gene transcription.
引用
收藏
页码:240 / 244
页数:5
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