The emerging role of SPOP protein in tumorigenesis and cancer therapy

被引：85

作者：

Song, Yizuo ^{[1
]}

Xu, Yichi ^{[1
]}

Pan, Chunyu ^{[1
]}

Yan, Linzhi ^{[1
]}

Wang, Zhi-wei ^{[2
,3
]}

Zhu, Xueqiong ^{[1
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, 109 Xueyuan Xi Rd, Wenzhou 325027, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 2, Ctr Sci Res, 109 Xueyuan Xi Rd, Wenzhou 325027, Zhejiang, Peoples R China

[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA

来源：

MOLECULAR CANCER | 2020年 / 19卷 / 01期

基金：

中国国家自然科学基金;

关键词：

SPOP; Oncoprotein; Tumor suppressor; Cancer; Therapy; TUMOR-SUPPRESSOR SPOP; UBIQUITIN-PROTEASOME SYSTEM; NF-KAPPA-B; PROSTATE-CANCER; POZ PROTEIN; ANDROGEN RECEPTOR; PROMOTES UBIQUITINATION; PROGESTERONE-RECEPTORS; ORDER OLIGOMERIZATION; METASTASIS SUPPRESSOR;

D O I：

10.1186/s12943-019-1124-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited oncogenic function in kidney cancer, suggesting that SPOP could exert its biological function in a cancer type-specific manner. The role of SPOP in thyroid, cervical, ovarian, bone and neurologic cancers has yet to be determined. In this review article, we describe the structure and regulation of SPOP in human cancer. Moreover, we highlight the critical role of SPOP in tumorigenesis based on three major categories: physiological evidence (animal models), pathological evidence (human cancer specimens) and biochemical evidence (downstream ubiquitin substrates). Furthermore, we note that SPOP could be a promising therapeutic target for cancer treatment.

引用

页数：13

共 140 条

[31] RING Domain E3 Ubiquitin Ligases [J].

Deshaies, Raymond J. ;

Joazeiro, Claudio A. P. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2009, 78 :399-434

[32] Progesterone action in breast, uterine, and ovarian cancers [J].

Diep, Caroline H. ;

Daniel, Andrea R. ;

Mauro, Laura J. ;

Knutson, Todd P. ;

Lange, Carol A. .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2015, 54 (02) :R31-R53

[33] Decreased expression of the SPOP gene is associated with poor prognosis in glioma [J].

Ding, Dacheng ;

Song, Tao ;

Jun, Wu ;

Tan, Zeming ;

Fang, Jiasheng .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2015, 46 (01) :333-341

[34]

Dong YP, 2019, AM J CANCER RES, V9, P1469

[35] Adaptor Protein Self-Assembly Drives the Control of a Cullin-RING Ubiquitin Ligase [J].

Errington, Wesley J. ;

Khan, M. Qasim ;

Bueler, Stephanie A. ;

Rubinstein, John L. ;

Chakrabartty, Avijit ;

Prive, Gilbert G. .

STRUCTURE, 2012, 20 (07) :1141-1153

[36] Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases [J].

Furukawa, M ;

He, YZJ ;

Borchers, C ;

Xiong, Y .

NATURE CELL BIOLOGY, 2003, 5 (11) :1001-1007

[37] SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression [J].

Gan, Wenjian ;

Dai, Xiangpeng ;

Lunardi, Andrea ;

Li, Zhen ;

Inuzuka, Hiroyuki ;

Liu, Pengda ;

Varmeh, Shoreh ;

Zhang, Jinfang ;

Cheng, Liang ;

Sun, Yin ;

Asara, John M. ;

Beck, Andrew H. ;

Huang, Jiaoti ;

Pandolfi, Pier Paolo ;

Wei, Wenyi .

MOLECULAR CELL, 2015, 59 (06) :917-930

[38]

Gao K, 2015, AM J CANCER RES, V5, P3210

[39] Clinico-pathological significance of the molecular alterations of the SPOP gene in prostate cancer [J].

Garcia-Flores, Maria ;

Casanova-Salas, Irene ;

Rubio-Briones, Jose ;

Calatrava, Ana ;

Dominguez-Escrig, Jose ;

Rubio, Luis ;

Ramirez-Backhaus, Miguel ;

Fernandez-Serra, Antonio ;

Garcia-Casado, Zaida ;

Antonio Lopez-Guerrero, Jose .

EUROPEAN JOURNAL OF CANCER, 2014, 50 (17) :2994-3002

[40] SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein [J].

Geng, C. ;

Kaochar, S. ;

Li, M. ;

Rajapakshe, K. ;

Fiskus, W. ;

Dong, J. ;

Foley, C. ;

Dong, B. ;

Zhang, L. ;

Kwon, O-J ;

Shah, S. S. ;

Bolaki, M. ;

Xin, L. ;

Ittmann, M. ;

O'Malley, B. W. ;

Coarfa, C. ;

Mitsiades, N. .

ONCOGENE, 2017, 36 (33) :4767-4777

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