The emerging role of SPOP protein in tumorigenesis and cancer therapy

被引：85

作者：

Song, Yizuo ^{[1
]}

Xu, Yichi ^{[1
]}

Pan, Chunyu ^{[1
]}

Yan, Linzhi ^{[1
]}

Wang, Zhi-wei ^{[2
,3
]}

Zhu, Xueqiong ^{[1
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, 109 Xueyuan Xi Rd, Wenzhou 325027, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 2, Ctr Sci Res, 109 Xueyuan Xi Rd, Wenzhou 325027, Zhejiang, Peoples R China

[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA

来源：

MOLECULAR CANCER | 2020年 / 19卷 / 01期

基金：

中国国家自然科学基金;

关键词：

SPOP; Oncoprotein; Tumor suppressor; Cancer; Therapy; TUMOR-SUPPRESSOR SPOP; UBIQUITIN-PROTEASOME SYSTEM; NF-KAPPA-B; PROSTATE-CANCER; POZ PROTEIN; ANDROGEN RECEPTOR; PROMOTES UBIQUITINATION; PROGESTERONE-RECEPTORS; ORDER OLIGOMERIZATION; METASTASIS SUPPRESSOR;

D O I：

10.1186/s12943-019-1124-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited oncogenic function in kidney cancer, suggesting that SPOP could exert its biological function in a cancer type-specific manner. The role of SPOP in thyroid, cervical, ovarian, bone and neurologic cancers has yet to be determined. In this review article, we describe the structure and regulation of SPOP in human cancer. Moreover, we highlight the critical role of SPOP in tumorigenesis based on three major categories: physiological evidence (animal models), pathological evidence (human cancer specimens) and biochemical evidence (downstream ubiquitin substrates). Furthermore, we note that SPOP could be a promising therapeutic target for cancer treatment.

引用

页数：13

共 140 条

[1] HDAC6 Regulates Androgen Receptor Hypersensitivity and Nuclear Localization via Modulating Hsp90 Acetylation in Castration-Resistant Prostate Cancer [J].

Ai, Junkui ;

Wang, Yujuan ;

Dar, Javid A. ;

Liu, June ;

Liu, Lingqi ;

Nelson, Joel B. ;

Wang, Zhou .

MOLECULAR ENDOCRINOLOGY, 2009, 23 (12) :1963-1972

[2] The Role of HDAC6 in Cancer [J].

Aldana-Masangkay, Grace I. ;

Sakamoto, Kathleen M. .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011,

[3] Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation [J].

An, Jian ;

Ren, Shancheng ;

Murphy, Stephen J. ;

Dalangood, Sumiya ;

Chang, Cunjie ;

Pang, Xiaodong ;

Cui, Yangyan ;

Wang, Liguo ;

Pan, Yunqian ;

Zhang, Xiaowei ;

Zhu, Yasheng ;

Wang, Chenji ;

Halling, Geoffrey C. ;

Cheng, Liang ;

Sukov, William R. ;

Karnes, R. Jeffrey ;

Vasmatzis, George ;

Zhang, Qing ;

Zhang, Jun ;

Cheville, John C. ;

Yan, Jun ;

Sun, Yinghao ;

Huang, Haojie .

MOLECULAR CELL, 2015, 59 (06) :904-916

[4]

[Anonymous], 2014, UROLOGY

[5] Common Musculoskeletal Tumors of Childhood and Adolescence [J].

Arndt, Carola A. S. ;

Rose, Peter S. ;

Folpe, Andrew L. ;

Laack, Nadia N. .

MAYO CLINIC PROCEEDINGS, 2012, 87 (05) :475-487

[6] Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer [J].

Barbieri, Christopher E. ;

Baca, Sylvan C. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE GENETICS, 2012, 44 (06) :685-U107

[7] STEROID-HORMONE RECEPTORS - MANY ACTORS IN SEARCH OF A PLOT [J].

BEATO, M ;

HERRLICH, P ;

SCHUTZ, G .

CELL, 1995, 83 (06) :851-857

[8] Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets [J].

Bedford, Lynn ;

Lowe, James ;

Dick, Lawrence R. ;

Mayer, R. John ;

Brownell, James E. .

NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (01) :29-46

[9] The genomic complexity of primary human prostate cancer [J].

Berger, Michael F. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Drier, Yotam ;

Cibulskis, Kristian ;

Sivachenko, Andrey Y. ;

Sboner, Andrea ;

Esgueva, Raquel ;

Pflueger, Dorothee ;

Sougnez, Carrie ;

Onofrio, Robert ;

Carter, Scott L. ;

Park, Kyung ;

Habegger, Lukas ;

Ambrogio, Lauren ;

Fennell, Timothy ;

Parkin, Melissa ;

Saksena, Gordon ;

Voet, Douglas ;

Ramos, Alex H. ;

Pugh, Trevor J. ;

Wilkinson, Jane ;

Fisher, Sheila ;

Winckler, Wendy ;

Mahan, Scott ;

Ardlie, Kristin ;

Baldwin, Jennifer ;

Simons, Jonathan W. ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Kantoff, Philip W. ;

Chin, Lynda ;

Gabriel, Stacey B. ;

Gerstein, Mark B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Tewari, Ashutosh ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE, 2011, 470 (7333) :214-220

[10] SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling [J].

Blattner, Mirjam ;

Liu, Deli ;

Robinson, Brian D. ;

Huang, Dennis ;

Poliakov, Anton ;

Gao, Dong ;

Nataraj, Srilakshmi ;

Deonarine, Lesa D. ;

Augello, Michael A. ;

Sailer, Verena ;

Ponnala, Lalit ;

Ittmann, Michael ;

Chinnaiyan, Arul M. ;

Sboner, Andrea ;

Chen, Yu ;

Rubin, Mark A. ;

Barbieri, Christopher E. .

CANCER CELL, 2017, 31 (03) :436-451

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