Catalytic Asymmetric Mannich Reaction of Glycine Derivatives with N-Tosylimines using Copper(I)/TF-BiphamPhos Complex

被引：45

作者：

Liang, Gang ^{[1
]}

Tong, Min-Chao ^{[1
]}

Tao, Haiyan ^{[1
]}

Wang, Chun-Jiang ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 11-12期

基金：

中国国家自然科学基金;

关键词：

asymmetric catalysis; diastereoselectivity; enantioselectivity; glycine Schiff bases; Mannich reaction; N-tosylimines; PHASE-TRANSFER CATALYSIS; SCHIFF-BASES; ENANTIOSELECTIVE SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; IMINES; TARTRATE; REVERSAL; ACIDS;

D O I：

10.1002/adsc.201000252

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The direct asymmetric Mannich reaction of glycine Schiff bases with N-tosylimines has been developed with the tetrakis(acetonitrile)copper(1) tetrafluoroborate [Cu(CH3CN)(4)BF4]/TF-BiphamPhos complex This catalytic system performs well over a broad range of substrates. furnishing anti-adducts of various alpha,beta-diamino acid esters in good yields with up to 94 6 diastereoselectivity and 97% enantioselectivity.

引用

页码：1851 / 1855

页数：5

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