Construction of Quaternary Allylic Amino Acid Derivatives through Palladium-Catalyzed Allylic Alkylation Reaction of Azlactones with Vinyl Aziridine

被引：1

作者：

Huang, Ke-Xin ^{[1
]}

Chen, Zhao-Yang ^{[1
]}

Liu, Xue-Guo ^{[1
]}

Ye, Hong-Yong ^{[1
]}

Gao, Wen-Chao ^{[2
]}

机构：

[1] Nanyang Inst Technol, Sch Biol & Chem Engn, Nanyang 473000, Henan, Peoples R China

[2] Nanyang Normal Univ, Sch Chem & Pharmaceut Engn, Nanyang 473000, Henan, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2022年 / 54卷 / 20期

关键词：

allylic alkylation; quaternary allylic amino acid derivatives; Pd-catalyzed; vinyl aziridine; azlactones; DYNAMIC KINETIC RESOLUTION; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; GAMMA-ADDITIONS; DESIGN; DIHYDROCOUMARINS; CYCLOADDITION; ACCESS; HETEROCYCLES; TERTIARY;

D O I：

10.1055/a-1878-8084

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient Pd-catalyzed allylic alkylation reaction of azlactones with vinyl aziridine has been achieved for the first time to access functionalized quaternary allylic amino acid derivatives (17 examples, up to 89% yield and 80% ee). Moreover, the broad scope and easy transformations of the products reinforce the value of this approach, which can enrich the chemistry of quaternary allylic amino acid derivatives.

引用

页码：4495 / 4502

页数：8

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