Microencapsulated ferrous sulfate to fortify cow milk: Absorption and distribution in mice

被引:0
作者
Boccio, JR
Zubillaga, MB
Caro, RA
Lysionek, AE
Salgueiro, MJ
Calmanovici, GP
Sarabia, MI
Weill, R
机构
[1] Univ Buenos Aires, Sch Pharm & Biochem, Dept Phys, Radioisotope Lab, RA-1113 Buenos Aires, DF, Argentina
[2] Ctr Res & Dev, Buenos Aires, DF, Argentina
关键词
milk; fortification; iron; metabolism; absorption;
D O I
暂无
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
To determine the absorption and biodistribution of iron from microencapsulated ferrous sulfate (SFE-171), used to fortify dairy products with iron, a comparative study in four groups of 30 mice each was carried out. In two of the groups, the absorption of iron from ferrous ascorbate in water (13.3+/-4.3%) and from ferrous sulfate in water (12.7+/-3.9%) was determined and taken as reference standards. In the third group the iron absorption from SFE-171 in milk was determined, giving a value of 12.1+/-4.2%, which statistically does not differ from the data obtained with either reference standard. In the fourth group, the absorption of iron from ferrous sulfate in milk showed a value of 7.7+/-3.4%, which statistically differs with a p<0.01 from the data corresponding to the other three groups. The biodistribution studies showed that the iron from SFE-171 follows the same metabolic pathway as the iron from the reference standards thus, giving a higher radioactivity percentage and radioactivity concentration in organs or systems, principally blood, that are closely related to iron metabolism. Our studies allow us to conclude that the iron from SFE-171 in milk follows the same behavior as the nonhemic iron, with a higher absorption than that of ferrous sulfate in milk.
引用
收藏
页码:381 / 389
页数:9
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