Phosphodiesterase inhibitors and inflammatory bowel disease: emerging therapies in inflammatory bowel disease

被引:29
作者
Keshavarzian, Ali [1 ]
Mutlu, Ece [1 ]
Guzman, Juan P. [1 ]
Forsyth, Christopher [1 ]
Banan, Ali [1 ]
机构
[1] Rush Univ, Ctr Med, Dept Internal Med, Div Digest Dis, Chicago, IL 60612 USA
关键词
Crohn s disease; phosphodiesterase; reactive oxygen species; tetomilast (OPC-6535); ulcerative colitis;
D O I
10.1517/13543784.16.9.1489
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Crohn's disease and ulcerative Colitis (UC) are common, chronic inflammatory bowel diseases (IBDs) characterized by episodes of life-altering symptoms such as diarrhea, bleeding, fecal urgency and incontinence, abdominal pain and cramps, and fever lasting weeks to months at a time. Existing treatments are 5-aminosalicyclates or immunosuppressants, but long-term control of 1131) is a major problem for a large number of patients. Phosphodiesterase 4 (PDE4) is a key enzyme in cell homeostasis and inflammation and its inhibition has been useful in diseases such as asthma and chronic obstructive pulmonary disease, rheumatoid arthritis and multiple sclerosis. This review focuses on the role of oxidative stress in IBD and the PDE4 inhibitor OPC-6535 (tetomilast), an investigational agent for the treatment of UC. The authors detail the clinical development of the compound and report and provide insight into some of the unpublished data from the recently completed multicenter Phase III trials in UC.
引用
收藏
页码:1489 / 1506
页数:18
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