[Ag2(aca)2]n and [Ag4(aca)4(NH3)2] (acaH=9-anthracenecarboxylic acid):: Synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities

被引：34

作者：

Curran, Robert

Lenehan, Joanne

McCann, Malachy ^{[1
]}

Kavanagh, Kevin

Devereux, Michael

Egan, Denise A.

Clifford, Grace

Keane, Kevin

Creaven, Bernadette S.

Mckee, Vickie

机构：

[1] Natl Univ Ireland Maynooth, Dept Chem, Maynooth, Kildare, Ireland

[2] Natl Univ Ireland Maynooth, Dept Biol, Maynooth, Kildare, Ireland

[3] Dublin Inst Technol, Dublin 2, Ireland

[4] Dublin Inst Technol, CPRD, Dublin 24, Ireland

[5] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2007年 / 10卷 / 10期

关键词：

9-anthracenecarboxylic acid; x-ray structure; Silver(I); anti-fungal; anti-bacterial; anti-cancer;

D O I：

10.1016/j.inoche.2007.06.021

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

[Ag-2(9-aca)(2)](n) and [Ag-4(9-aca)(4)(NH3)(2)] (9-acaH = 9-anthracenecarboxylic acid) have been prepared and structurally characterized. [Ag-2(9-aca)(2)](n), consists of polymeric ribbons of linked disilver(I) syn-syn bridged dicarboxylate units. [Ag-4(9-aca)(4)(NH3)(2)] is tetrameric and centrosymmetric, with two syn-syn bridging carboxylates linked to the bimetallic Ag-Ag core and a further two syn-anti bridged carboxylate ligands in the equatorial plane, being coordinated to one Ag in the bimetallic core and to a second Ag, with the latter also bonded to an NH3 ligand. In vitro studies show that both complexes are extremely cytotoxic against selected human fungal and bacterial pathogens, and each complex also greatly inhibits the growth of two mammalian cancer cell lines. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：1149 / 1153

页数：5

共 11 条

[1] Synthesis, X-ray crystal structure, anti-fungal and anti-cancer activity of [Ag2(NH3)2(salH)2] (salH2= salicylic acid) [J].