Mind the Gap: Lack of Association between KIR3DL1*004/HLA-Bw4-Induced Natural Killer Cell Function and Protection from HIV Infection

被引：26
作者：
Parsons, Matthew S. [1 ,2 ,3 ]
Boulet, Salix [1 ,2 ]
Song, Rujun [1 ,2 ,3 ]
Bruneau, Julie [6 ]
Shoukry, Naglaa H. [6 ]
Routy, Jean-Pierre [1 ,2 ,4 ,5 ]
Tsoukas, Christos M. [1 ,2 ,3 ]
Bernard, Nicole F. [1 ,2 ,3 ]
机构：
[1] McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ H3G 1A4, Canada
[2] McGill Univ, Ctr Hlth, Div Clin Immunol & Allergy, Montreal, PQ H3G 1A4, Canada
[3] McGill Univ, Ctr Hlth, Div Expt Med, Montreal, PQ H3G 1A4, Canada
[4] McGill Univ, Ctr Hlth, Immunodeficiency Serv, Montreal, PQ H3G 1A4, Canada
[5] McGill Univ, Ctr Hlth, Div Hematol, Montreal, PQ H3G 1A4, Canada
[6] CHU Montreal, Hop St Luc, Ctr Rech, Montreal, PQ, Canada
来源：
JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷
基金：
加拿大健康研究院;
关键词：
COMPLEX CLASS-I; NK-CELLS; HLA-B; KIR3DL1; ALLELES; INDIVIDUALS; PROGRESSION; EXPRESSION; EDUCATION; RECEPTOR;
D O I：
10.1086/655966
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Several combinations of genes encoding KIR3DL1 alleles and their HLA-Bw4 ligands have been linked with favorable outcomes upon exposure to or infection with human immunodeficiency virus (HIV). Some protective KIR3DL1/HLA-Bw4 combinations confer elevated natural killer (NK) cell functional potential. The K562-stimulated functionality of NK cells from KIR3DL1*004/HLA-Bw4 and control genotype carriers was assessed by flow cytometry and found to be higher in KIR3DL1*004/HLA-Bw4 carriers. However, a comparison of the frequency of this combined genotype among HIV-exposed uninfected and HIV-infected subjects revealed no between-group differences. Thus, despite its ability to license NK cells, KIR3DL1*004/HLA-Bw4 is not associated with a reduced risk of infection.
引用
收藏
页码：S356 / S360
页数：5
相关论文
共 20 条
  • [1] Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes
    Alter, Galit
    Martin, Maureen P.
    Teigen, Nickolas
    Carr, William H.
    Suscovich, Todd J.
    Schneidewind, Arne
    Streeck, Hendrik
    Waring, Michael
    Meier, Angela
    Brander, Christian
    Lifson, Jeffrey D.
    Allen, Todd M.
    Carrington, Mary
    Altfeld, Marcus
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (12) : 3027 - 3036
  • [2] Human NK cell education by inhibitory receptors for MHC class I
    Anfossi, Nicolas
    Andre, Pascale
    Guia, Sophie
    Falk, Christine S.
    Roetynck, Sophie
    Stewart, C. Andrew
    Breso, Violette
    Frassati, Coralie
    Reviron, Denis
    Middleton, Derek
    Romagne, Francois
    Ugolini, Sophie
    Vivier, Eric
    [J]. IMMUNITY, 2006, 25 (02) : 331 - 342
  • [3] Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals
    Boulet, Salix
    Sharafi, Saeid
    Simic, Nancy
    Bruneau, Julie
    Routy, Jean-Pierre
    Tsoukas, Christos A.
    Bernard, Nicole F.
    [J]. AIDS, 2008, 22 (05) : 595 - 599
  • [4] HIV Protective KIR3DL1 and HLA-B Genotypes Influence NK Cell Function Following Stimulation with HLA-Devoid Cells
    Boulet, Salix
    Song, Rujun
    Kamya, Philomena
    Bruneau, Julie
    Shoukry, Naglaa H.
    Tsoukas, Christos M.
    Bernard, Nicole F.
    [J]. JOURNAL OF IMMUNOLOGY, 2010, 184 (04) : 2057 - 2064
  • [5] NK cell education: not an on-off switch but a tunable rheostat
    Brodin, Petter
    Karre, Klas
    Hoglund, Petter
    [J]. TRENDS IN IMMUNOLOGY, 2009, 30 (04) : 143 - 149
  • [6] Cutting edge:: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation
    Carr, William H.
    Rosen, David B.
    Arase, Hisashi
    Nixon, Douglas F.
    Michaelsson, Jakob
    Lanier, Lewis L.
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 178 (02) : 647 - 651
  • [7] A Role for cis Interaction between the Inhibitory Ly49A Receptor and MHIC Class I for Natural Killer Cell Education
    Chalifour, Anick
    Scarpellino, Leonardo
    Back, Jonathan
    Brodin, Petter
    Devevre, Estelle
    Gros, Frederic
    Levy, Frederic
    Leclercq, Georges
    Hoglund, Petter
    Beermann, Friedrich
    Held, Werner
    [J]. IMMUNITY, 2009, 30 (03) : 337 - 347
  • [8] Licensing of natural killer cells by host major histocompatibility complex class I molecules
    Kim, S
    Poursine-Laurent, J
    Truscott, SM
    Lybarger, L
    Song, YJ
    Yang, LP
    French, AR
    Sunwoo, JB
    Lemieux, S
    Hansen, TH
    Yokoyama, WM
    [J]. NATURE, 2005, 436 (7051) : 709 - 713
  • [9] HLA alleles determine differences in human natural killer cell responsiveness and potency
    Kim, Surl
    Sunwoo, John B.
    Yang, Liping
    Choi, Taewoong
    Song, Yun-Jeong
    French, Anthony R.
    Vlahiotis, Anna
    Piccirillo, Jay F.
    Cella, Marina
    Colonna, Marco
    Mohanakumar, Thalachallour
    Hsu, Katharine C.
    Dupont, Bo
    Yokoyama, Wayne M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (08) : 3053 - 3058
  • [10] NK cell recognition
    Lanier, LL
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2005, 23 : 225 - 274
12